Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment

Moses M. Kasembeli; Uddalak Bharadwaj; Prema Robinson; David J. Tweardy

doi:10.3390/ijms19082299

Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment

Moses M. Kasembeli, Uddalak Bharadwaj, Prema Robinson, David J. Tweardy

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Review article › peer-review

121 Scopus citations

Abstract

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.

Original language	English (US)
Article number	2299
Journal	International journal of molecular sciences
Volume	19
Issue number	8
DOIs	https://doi.org/10.3390/ijms19082299
State	Published - Aug 5 2018

Keywords

Asthma
Cachexia
Crohn’s disease (CD)
Fibrosis
Inflammatory bowel disease (IBD)
STAT3
Ulcerative colitis (UC)

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms19082299

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title = "Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment",

abstract = "Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.",

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AU - Robinson, Prema

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AB - Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.

KW - Asthma

KW - Cachexia

KW - Crohn’s disease (CD)

KW - Fibrosis

KW - Inflammatory bowel disease (IBD)

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Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment

Abstract

Keywords

ASJC Scopus subject areas

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