Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment

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25 Scopus citations

Abstract

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.

Original languageEnglish (US)
Article number2299
JournalInternational journal of molecular sciences
Volume19
Issue number8
DOIs
StatePublished - Aug 5 2018

Keywords

  • Asthma
  • Cachexia
  • Crohn’s disease (CD)
  • Fibrosis
  • Inflammatory bowel disease (IBD)
  • STAT3
  • Ulcerative colitis (UC)

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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