Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.

Original languageEnglish (US)
Article number2299
JournalInternational journal of molecular sciences
Volume19
Issue number8
DOIs
StatePublished - Aug 5 2018

Fingerprint

fibrosis
Fibrosis
Inflammation
homeostasis
STAT3 Transcription Factor
Transcription
Transducers
Interleukin-6
transducers
Homeostasis
Chronic Disease
Chemical activation
activation
Cytokines
Wounds and Injuries
cells

Keywords

  • Asthma
  • Cachexia
  • Crohn’s disease (CD)
  • Fibrosis
  • Inflammatory bowel disease (IBD)
  • STAT3
  • Ulcerative colitis (UC)

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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title = "Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment",
abstract = "Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.",
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AU - Bharadwaj, Uddalak

AU - Robinson, Prema

AU - Tweardy, David J.

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AB - Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.

KW - Asthma

KW - Cachexia

KW - Crohn’s disease (CD)

KW - Fibrosis

KW - Inflammatory bowel disease (IBD)

KW - STAT3

KW - Ulcerative colitis (UC)

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