Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking

Judith Alferink, Anna Tafuri, Dietmar Vestweber, Rupert Hallmann, Peter J. Haemmerling, Bernd Arnold

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Self tolerance is acquired by the developing immune system. As reported here, particular properties of the neonatal tissue contribute to this process. Neonatal skin, but not adult skin, was accessible for naive CD8 T cells. In mouse bone marrow chimeras generated at different ages, recent thymic emigrants were tolerized to a skin-expressed major histocompatibility complex class I antigen only during a neonatal period but not during adulthood. Blockade of T cell migration neonatally prevented tolerance induction. Thus, T cell trafficking through nonlymphoid tissues in the neonate is crucial for the establishment of self tolerance to sessile, skin- expressed antigens.

Original languageEnglish (US)
Pages (from-to)1338-1341
Number of pages4
JournalScience
Volume282
Issue number5392
DOIs
StatePublished - Nov 13 1998

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T-Lymphocytes
Self Tolerance
Antigens
Skin
Histocompatibility Antigens Class I
Major Histocompatibility Complex
Cell Movement
Immune System
Bone Marrow
Newborn Infant

ASJC Scopus subject areas

  • General

Cite this

Alferink, J., Tafuri, A., Vestweber, D., Hallmann, R., Haemmerling, P. J., & Arnold, B. (1998). Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking. Science, 282(5392), 1338-1341. https://doi.org/10.1126/science.282.5392.1338

Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking. / Alferink, Judith; Tafuri, Anna; Vestweber, Dietmar; Hallmann, Rupert; Haemmerling, Peter J.; Arnold, Bernd.

In: Science, Vol. 282, No. 5392, 13.11.1998, p. 1338-1341.

Research output: Contribution to journalArticle

Alferink, J, Tafuri, A, Vestweber, D, Hallmann, R, Haemmerling, PJ & Arnold, B 1998, 'Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking', Science, vol. 282, no. 5392, pp. 1338-1341. https://doi.org/10.1126/science.282.5392.1338
Alferink, Judith ; Tafuri, Anna ; Vestweber, Dietmar ; Hallmann, Rupert ; Haemmerling, Peter J. ; Arnold, Bernd. / Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking. In: Science. 1998 ; Vol. 282, No. 5392. pp. 1338-1341.
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