Controversies over the role of radiation therapy for ductal carcinoma in situ

Benjamin D. Smith, Grace L. Smith, Thomas A. Buchholz

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Ductal carcinoma in situ is a premalignant disease of the breast with a rapidly rising incidence. For women with localized ductal carcinoma in situ, randomized trials have shown that radiation therapy following conservative surgery lowers the relative risk of progression to invasive disease by 60%. Therefore, following conservative surgery, radiation therapy to the breast is generally considered a reasonable standard of care. However, several clinical trials have investigated the safety of conservative surgery alone without radiation for select women with small tumors of low histologic grade excised with widely negative margins. At present, results of these trials are conflicting, and, therefore, radiation therapy is generally recommended following conservative surgery, even for patients with favorable pathologic characteristic.

Original languageEnglish (US)
Pages (from-to)433-441
Number of pages9
JournalExpert review of anticancer therapy
Volume8
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • Breast cancer
  • Conservative surgery
  • DCIS
  • Ductal carcinoma in situ
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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