Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance

Bao Cun Sun, Yan Sun, Xiu Lan Zhao, Jian Wang, Xin Wang, Yan Xue Liu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To study the expression of matrix metalloproteinases (MMP) -2 and tissue inhibitor of metalloproteinase (TIMP) -2 in tumor cells of synovial sarcoma and its clinical significance. Methods: Expression of MMP-2 and TIMP-2 in tumor cells of 72 cases of synovial sarcoma was studied by immunohistochemistry. The profile was correlated with clinicopathologic parameters, microvessel density (MVD) (analyzed by CD31 immunostaining) and survival rate. Results: (1) There was a statistically significant negative correlation between expression of MMP-2 and TIMP-2 (r = -0.290 and P = 0.013). (2) The proportion of high MMP-2 expression to low TIMP-2 expression in patients with tumor metastasis was significantly higher than that in patients without metastasis (P = 0.010 and 0.002 respectively). (3) MVD of patients with high MMP-2 expression was higher than that in the low MMP-2 expression group (P = 0.005). MVD of patients with high TIMP-2 expression was lower than that in the low TIMP-2 expression group (P = 0.048). (4) Low TIMP-2 expression significantly correlated with poor prognosis of patients with synovial sarcoma, by univariate and multivariate survival analysis (P = 0.002 and 0.016 respectively). Conclusions: Expression of MMP-2 and TIMP-2 correlates with metastatic potential and tumor angiogenesis in synovial sarcoma. Low TIMP-2 expression often indicates poor prognosis and unfavorable clinical outcomes.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalChinese Journal of Pathology
Volume35
Issue number3
StatePublished - Mar 1 2006

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Synovial Sarcoma
Tissue Inhibitor of Metalloproteinase-2
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinase 2
Neoplasms
Microvessels
Neoplasm Metastasis
Survival Analysis
Multivariate Analysis
Survival Rate
Immunohistochemistry

Keywords

  • Matrix metalloproteinases-2
  • Neovascularization, pathologic
  • Sarcoma, synovial
  • Tissue inhibitor of metalloproteinase-2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance. / Sun, Bao Cun; Sun, Yan; Zhao, Xiu Lan; Wang, Jian; Wang, Xin; Liu, Yan Xue.

In: Chinese Journal of Pathology, Vol. 35, No. 3, 01.03.2006, p. 155-158.

Research output: Contribution to journalArticle

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title = "Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance",
abstract = "Objective: To study the expression of matrix metalloproteinases (MMP) -2 and tissue inhibitor of metalloproteinase (TIMP) -2 in tumor cells of synovial sarcoma and its clinical significance. Methods: Expression of MMP-2 and TIMP-2 in tumor cells of 72 cases of synovial sarcoma was studied by immunohistochemistry. The profile was correlated with clinicopathologic parameters, microvessel density (MVD) (analyzed by CD31 immunostaining) and survival rate. Results: (1) There was a statistically significant negative correlation between expression of MMP-2 and TIMP-2 (r = -0.290 and P = 0.013). (2) The proportion of high MMP-2 expression to low TIMP-2 expression in patients with tumor metastasis was significantly higher than that in patients without metastasis (P = 0.010 and 0.002 respectively). (3) MVD of patients with high MMP-2 expression was higher than that in the low MMP-2 expression group (P = 0.005). MVD of patients with high TIMP-2 expression was lower than that in the low TIMP-2 expression group (P = 0.048). (4) Low TIMP-2 expression significantly correlated with poor prognosis of patients with synovial sarcoma, by univariate and multivariate survival analysis (P = 0.002 and 0.016 respectively). Conclusions: Expression of MMP-2 and TIMP-2 correlates with metastatic potential and tumor angiogenesis in synovial sarcoma. Low TIMP-2 expression often indicates poor prognosis and unfavorable clinical outcomes.",
keywords = "Matrix metalloproteinases-2, Neovascularization, pathologic, Sarcoma, synovial, Tissue inhibitor of metalloproteinase-2",
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T1 - Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance

AU - Sun, Bao Cun

AU - Sun, Yan

AU - Zhao, Xiu Lan

AU - Wang, Jian

AU - Wang, Xin

AU - Liu, Yan Xue

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Objective: To study the expression of matrix metalloproteinases (MMP) -2 and tissue inhibitor of metalloproteinase (TIMP) -2 in tumor cells of synovial sarcoma and its clinical significance. Methods: Expression of MMP-2 and TIMP-2 in tumor cells of 72 cases of synovial sarcoma was studied by immunohistochemistry. The profile was correlated with clinicopathologic parameters, microvessel density (MVD) (analyzed by CD31 immunostaining) and survival rate. Results: (1) There was a statistically significant negative correlation between expression of MMP-2 and TIMP-2 (r = -0.290 and P = 0.013). (2) The proportion of high MMP-2 expression to low TIMP-2 expression in patients with tumor metastasis was significantly higher than that in patients without metastasis (P = 0.010 and 0.002 respectively). (3) MVD of patients with high MMP-2 expression was higher than that in the low MMP-2 expression group (P = 0.005). MVD of patients with high TIMP-2 expression was lower than that in the low TIMP-2 expression group (P = 0.048). (4) Low TIMP-2 expression significantly correlated with poor prognosis of patients with synovial sarcoma, by univariate and multivariate survival analysis (P = 0.002 and 0.016 respectively). Conclusions: Expression of MMP-2 and TIMP-2 correlates with metastatic potential and tumor angiogenesis in synovial sarcoma. Low TIMP-2 expression often indicates poor prognosis and unfavorable clinical outcomes.

AB - Objective: To study the expression of matrix metalloproteinases (MMP) -2 and tissue inhibitor of metalloproteinase (TIMP) -2 in tumor cells of synovial sarcoma and its clinical significance. Methods: Expression of MMP-2 and TIMP-2 in tumor cells of 72 cases of synovial sarcoma was studied by immunohistochemistry. The profile was correlated with clinicopathologic parameters, microvessel density (MVD) (analyzed by CD31 immunostaining) and survival rate. Results: (1) There was a statistically significant negative correlation between expression of MMP-2 and TIMP-2 (r = -0.290 and P = 0.013). (2) The proportion of high MMP-2 expression to low TIMP-2 expression in patients with tumor metastasis was significantly higher than that in patients without metastasis (P = 0.010 and 0.002 respectively). (3) MVD of patients with high MMP-2 expression was higher than that in the low MMP-2 expression group (P = 0.005). MVD of patients with high TIMP-2 expression was lower than that in the low TIMP-2 expression group (P = 0.048). (4) Low TIMP-2 expression significantly correlated with poor prognosis of patients with synovial sarcoma, by univariate and multivariate survival analysis (P = 0.002 and 0.016 respectively). Conclusions: Expression of MMP-2 and TIMP-2 correlates with metastatic potential and tumor angiogenesis in synovial sarcoma. Low TIMP-2 expression often indicates poor prognosis and unfavorable clinical outcomes.

KW - Matrix metalloproteinases-2

KW - Neovascularization, pathologic

KW - Sarcoma, synovial

KW - Tissue inhibitor of metalloproteinase-2

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