TY - JOUR
T1 - Correlation between prognosis and bone marrow chromosomal patterns in children with acute nonlymphocytic leukemia
T2 - Similarities and differences compared to adults
AU - Benedict, W. F.
AU - Lange, M.
AU - Greene, J.
AU - Derencsenyi, A.
AU - Alfi, O. S.
PY - 1979
Y1 - 1979
N2 - The chromosomal complement of twenty-eight children with the diagnosis of acute nonlymphocytic leukemia (ANLL) were examined. An abnormal cytogenetic pattern was found in 50% of these patients, which is similar to the results in adults with ANLL. Unlike the reports in adult patients, however, no specific chromosomal changes were found. This observation may imply that the etiology and mechanisms by which abnormal clones develop in ANLL could differ significantly between children and adults. Those patients with chromosomal abnormalities in their initial bone marrow sample had a median survival of 7.1 mth, whereas those with a normal diploid pattern in their bone marrow had a median survival of 20.5 mth (1-sided, p = 0.04). If all metaphases were abnormal, the median survival was only 3 mth.
AB - The chromosomal complement of twenty-eight children with the diagnosis of acute nonlymphocytic leukemia (ANLL) were examined. An abnormal cytogenetic pattern was found in 50% of these patients, which is similar to the results in adults with ANLL. Unlike the reports in adult patients, however, no specific chromosomal changes were found. This observation may imply that the etiology and mechanisms by which abnormal clones develop in ANLL could differ significantly between children and adults. Those patients with chromosomal abnormalities in their initial bone marrow sample had a median survival of 7.1 mth, whereas those with a normal diploid pattern in their bone marrow had a median survival of 20.5 mth (1-sided, p = 0.04). If all metaphases were abnormal, the median survival was only 3 mth.
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U2 - 10.1182/blood.v54.4.818.818
DO - 10.1182/blood.v54.4.818.818
M3 - Article
C2 - 289424
AN - SCOPUS:0018692322
SN - 0006-4971
VL - 54
SP - 818
EP - 823
JO - Blood
JF - Blood
IS - 4
ER -