[Correlation of cervical lymphatic metastasis to prognosis of glottic carcinoma: a report of 333 cases].

Quan Zhang, Fei Yun Lai, Zhu Ming Guo, Zong Yuan Zeng, Ming Song, Wen Bin Yu, Chuan Sheng Yang

Research output: Contribution to journalArticle

Abstract

Cervical lymph node metastasis rate of glottic carcinoma is low. How to deal with cervical adenopathy remains controversial. This study was to explore the factors relate to cervical lymphatic metastasis of glottic carcinoma. Clinical data of 333 patients with glottic carcinoma, treated at Cancer Center of Sun Yat-sen University from Jan. 1, 1992 to Dec. 31, 2000, were reviewed. Distribution of cervical adenopathy, prognosis, and neck management were analyzed. The overall lymphatic metastasis rate was 9.61% (32/333); the occult lymphatic metastasis rate was 6.24% (20/321). Most metastatic lymph nodes located at ipsilateral levels II, III and IV (28/32). The pathologic grade had no correlation to the overall lymphatic metastasis rate (P=0.092), and occult lymphatic metastasis rate (P=0.067). The overall lymphatic metastasis rate (P=0.002) and occult lymphatic metastasis rate (P=0.015) rose up following with increased T stage. Neck selective radiotherapy for the patients at stage cN0 had no significant impact on occult lymph node metastasis rate (P=0.363). The 3-and 5-year survival rates were significantly lower in cN+ patients than in cN0 patients (56.25% vs. 88.70%, 46.67% vs. 85.37%, P<0.001), significantly lower in the cN+ patients with occult lymph node metastasis than in the cN+ patients without lymph node metastasis (68.18% vs. 89.00%, 63.31% vs. 85.55%, P=0.005), and significantly lower in naive cN+ patients than in the naive cN0 patients with occult lymph node metastasis (41.67% vs. 68.18%, 16.67% vs. 63.31%, P=0.004). Most metastatic lymph nodes of glottic carcinoma locate at ipsilateral levels II, III and IV, especially at level II. Cervical lymphatic metastasis affects the prognosis of glottic carcinoma.

Original languageEnglish (US)
Pages (from-to)1138-1142
Number of pages5
JournalAi zheng = Aizheng = Chinese journal of cancer
Volume26
Issue number10
StatePublished - Jan 1 2007

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Lymphatic Metastasis
Tongue
Carcinoma
Lymph Nodes
Neoplasm Metastasis
Neck
Solar System
Radiotherapy
Survival Rate

ASJC Scopus subject areas

  • Oncology

Cite this

[Correlation of cervical lymphatic metastasis to prognosis of glottic carcinoma : a report of 333 cases]. / Zhang, Quan; Lai, Fei Yun; Guo, Zhu Ming; Zeng, Zong Yuan; Song, Ming; Yu, Wen Bin; Yang, Chuan Sheng.

In: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 26, No. 10, 01.01.2007, p. 1138-1142.

Research output: Contribution to journalArticle

Zhang, Quan ; Lai, Fei Yun ; Guo, Zhu Ming ; Zeng, Zong Yuan ; Song, Ming ; Yu, Wen Bin ; Yang, Chuan Sheng. / [Correlation of cervical lymphatic metastasis to prognosis of glottic carcinoma : a report of 333 cases]. In: Ai zheng = Aizheng = Chinese journal of cancer. 2007 ; Vol. 26, No. 10. pp. 1138-1142.
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title = "[Correlation of cervical lymphatic metastasis to prognosis of glottic carcinoma: a report of 333 cases].",
abstract = "Cervical lymph node metastasis rate of glottic carcinoma is low. How to deal with cervical adenopathy remains controversial. This study was to explore the factors relate to cervical lymphatic metastasis of glottic carcinoma. Clinical data of 333 patients with glottic carcinoma, treated at Cancer Center of Sun Yat-sen University from Jan. 1, 1992 to Dec. 31, 2000, were reviewed. Distribution of cervical adenopathy, prognosis, and neck management were analyzed. The overall lymphatic metastasis rate was 9.61{\%} (32/333); the occult lymphatic metastasis rate was 6.24{\%} (20/321). Most metastatic lymph nodes located at ipsilateral levels II, III and IV (28/32). The pathologic grade had no correlation to the overall lymphatic metastasis rate (P=0.092), and occult lymphatic metastasis rate (P=0.067). The overall lymphatic metastasis rate (P=0.002) and occult lymphatic metastasis rate (P=0.015) rose up following with increased T stage. Neck selective radiotherapy for the patients at stage cN0 had no significant impact on occult lymph node metastasis rate (P=0.363). The 3-and 5-year survival rates were significantly lower in cN+ patients than in cN0 patients (56.25{\%} vs. 88.70{\%}, 46.67{\%} vs. 85.37{\%}, P<0.001), significantly lower in the cN+ patients with occult lymph node metastasis than in the cN+ patients without lymph node metastasis (68.18{\%} vs. 89.00{\%}, 63.31{\%} vs. 85.55{\%}, P=0.005), and significantly lower in naive cN+ patients than in the naive cN0 patients with occult lymph node metastasis (41.67{\%} vs. 68.18{\%}, 16.67{\%} vs. 63.31{\%}, P=0.004). Most metastatic lymph nodes of glottic carcinoma locate at ipsilateral levels II, III and IV, especially at level II. Cervical lymphatic metastasis affects the prognosis of glottic carcinoma.",
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AB - Cervical lymph node metastasis rate of glottic carcinoma is low. How to deal with cervical adenopathy remains controversial. This study was to explore the factors relate to cervical lymphatic metastasis of glottic carcinoma. Clinical data of 333 patients with glottic carcinoma, treated at Cancer Center of Sun Yat-sen University from Jan. 1, 1992 to Dec. 31, 2000, were reviewed. Distribution of cervical adenopathy, prognosis, and neck management were analyzed. The overall lymphatic metastasis rate was 9.61% (32/333); the occult lymphatic metastasis rate was 6.24% (20/321). Most metastatic lymph nodes located at ipsilateral levels II, III and IV (28/32). The pathologic grade had no correlation to the overall lymphatic metastasis rate (P=0.092), and occult lymphatic metastasis rate (P=0.067). The overall lymphatic metastasis rate (P=0.002) and occult lymphatic metastasis rate (P=0.015) rose up following with increased T stage. Neck selective radiotherapy for the patients at stage cN0 had no significant impact on occult lymph node metastasis rate (P=0.363). The 3-and 5-year survival rates were significantly lower in cN+ patients than in cN0 patients (56.25% vs. 88.70%, 46.67% vs. 85.37%, P<0.001), significantly lower in the cN+ patients with occult lymph node metastasis than in the cN+ patients without lymph node metastasis (68.18% vs. 89.00%, 63.31% vs. 85.55%, P=0.005), and significantly lower in naive cN+ patients than in the naive cN0 patients with occult lymph node metastasis (41.67% vs. 68.18%, 16.67% vs. 63.31%, P=0.004). Most metastatic lymph nodes of glottic carcinoma locate at ipsilateral levels II, III and IV, especially at level II. Cervical lymphatic metastasis affects the prognosis of glottic carcinoma.

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