Correlation of Circulating Tumor Cell Measurements with 3D Quantitative Tumor Characterization to Predict Clinical Outcomes in Cancer

Sweet Ping Ng, Clifton David Fuller, Heath Skinner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a deadly disease which in many cases is managed with a combination of radiation and chemotherapy. Unfortunately, the ability to monitor treatment response in real time is limited. Thus, truly individualized therapy remains an unrealized goal. We have previously investigated the possibility of combining advanced imaging using magnetic resonance imaging (MRI) combined with the analysis of circulating tumor cells to classify response in HNSCC as part of a prospective trial (PREDICT-HN). An adaption of the methodology from that trial is described herein in hopes of allowing for recapitulation and further development of this exciting methodology.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages135-141
Number of pages7
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2174
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Circulating tumor cell
  • Head and neck cancer
  • Imaging
  • MRI
  • Radiotherapy

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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