Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma

Gui Fang Guo, Ru Hua Xie, An-kui Yang, Zhi Hua Chen, Qiu-Liang Wu, Wei Wei Liu, Shen Ming Ou, Liang Ping Xia, Ming-Yuan Chen, Jin Xin Zhang

Research output: Contribution to journalArticle

Abstract

BACKGROUND & OBJECTIVE: Tumor markers which relate to cell proliferation and metabolism have seldom been studied in maxillary sinus cancer. This study was conducted to identify the correlation of glutathione S-transferase pi (GST-pi) and proliferating cell nuclear antigen (PCNA) expression to prognosis of advanced maxillary sinus squamous cell carcinoma (SCC). METHODS: The expression of GST-pi and PCNA in 54 specimens of maxillary sinus SCC, 29 specimens of benign maxillary tumor, and 20 specimens of normal nasal mucosa was detected by immunohistochemistry. The correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus SCC was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model. RESULTS: The overexpression rates of GST-pi and PCNA were significantly higher in maxillary sinus SCC than in benign maxillary tumor and normal nasal mucosa (74.1% vs. 89.6% and 15.0%, P<0.01; 79.6% vs. 3.4% and 0, P<0.01). The 5-year survival rate was significantly higher in advanced maxillary sinus SCC patients with high expression of GST-pi than in the patients with low expression of GST-pi (34.5% vs. 21.2%, P=0.025); the difference between the patients with high and low expression of PCNA was not significant (18.0% vs. 27.0%, P=0.890). The expression of GST-pi was an independent prognostic factor of advanced maxillary sinus SCC (P=0.039, odds ratio>1). CONCLUSION: The overexpression of GST-pi is an independent prognostic factor of advanced maxillary sinus SCC, but that of PCNA isn't.

Original languageEnglish (US)
Pages (from-to)1267-1271
Number of pages5
JournalAi zheng = Aizheng = Chinese journal of cancer
Volume24
Issue number10
StatePublished - Jan 1 2005

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Glutathione S-Transferase pi
Maxillary Sinus
Proliferating Cell Nuclear Antigen
Squamous Cell Carcinoma
Nasal Mucosa
Maxillary Sinus Neoplasms
Tumor Biomarkers
Proportional Hazards Models
Neoplasms
Immunohistochemistry
Cell Proliferation

ASJC Scopus subject areas

  • Oncology

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Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma. / Guo, Gui Fang; Xie, Ru Hua; Yang, An-kui; Chen, Zhi Hua; Wu, Qiu-Liang; Liu, Wei Wei; Ou, Shen Ming; Xia, Liang Ping; Chen, Ming-Yuan; Zhang, Jin Xin.

In: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 24, No. 10, 01.01.2005, p. 1267-1271.

Research output: Contribution to journalArticle

Guo, Gui Fang ; Xie, Ru Hua ; Yang, An-kui ; Chen, Zhi Hua ; Wu, Qiu-Liang ; Liu, Wei Wei ; Ou, Shen Ming ; Xia, Liang Ping ; Chen, Ming-Yuan ; Zhang, Jin Xin. / Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma. In: Ai zheng = Aizheng = Chinese journal of cancer. 2005 ; Vol. 24, No. 10. pp. 1267-1271.
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abstract = "BACKGROUND & OBJECTIVE: Tumor markers which relate to cell proliferation and metabolism have seldom been studied in maxillary sinus cancer. This study was conducted to identify the correlation of glutathione S-transferase pi (GST-pi) and proliferating cell nuclear antigen (PCNA) expression to prognosis of advanced maxillary sinus squamous cell carcinoma (SCC). METHODS: The expression of GST-pi and PCNA in 54 specimens of maxillary sinus SCC, 29 specimens of benign maxillary tumor, and 20 specimens of normal nasal mucosa was detected by immunohistochemistry. The correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus SCC was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model. RESULTS: The overexpression rates of GST-pi and PCNA were significantly higher in maxillary sinus SCC than in benign maxillary tumor and normal nasal mucosa (74.1{\%} vs. 89.6{\%} and 15.0{\%}, P<0.01; 79.6{\%} vs. 3.4{\%} and 0, P<0.01). The 5-year survival rate was significantly higher in advanced maxillary sinus SCC patients with high expression of GST-pi than in the patients with low expression of GST-pi (34.5{\%} vs. 21.2{\%}, P=0.025); the difference between the patients with high and low expression of PCNA was not significant (18.0{\%} vs. 27.0{\%}, P=0.890). The expression of GST-pi was an independent prognostic factor of advanced maxillary sinus SCC (P=0.039, odds ratio>1). CONCLUSION: The overexpression of GST-pi is an independent prognostic factor of advanced maxillary sinus SCC, but that of PCNA isn't.",
author = "Guo, {Gui Fang} and Xie, {Ru Hua} and An-kui Yang and Chen, {Zhi Hua} and Qiu-Liang Wu and Liu, {Wei Wei} and Ou, {Shen Ming} and Xia, {Liang Ping} and Ming-Yuan Chen and Zhang, {Jin Xin}",
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T1 - Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma

AU - Guo, Gui Fang

AU - Xie, Ru Hua

AU - Yang, An-kui

AU - Chen, Zhi Hua

AU - Wu, Qiu-Liang

AU - Liu, Wei Wei

AU - Ou, Shen Ming

AU - Xia, Liang Ping

AU - Chen, Ming-Yuan

AU - Zhang, Jin Xin

PY - 2005/1/1

Y1 - 2005/1/1

N2 - BACKGROUND & OBJECTIVE: Tumor markers which relate to cell proliferation and metabolism have seldom been studied in maxillary sinus cancer. This study was conducted to identify the correlation of glutathione S-transferase pi (GST-pi) and proliferating cell nuclear antigen (PCNA) expression to prognosis of advanced maxillary sinus squamous cell carcinoma (SCC). METHODS: The expression of GST-pi and PCNA in 54 specimens of maxillary sinus SCC, 29 specimens of benign maxillary tumor, and 20 specimens of normal nasal mucosa was detected by immunohistochemistry. The correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus SCC was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model. RESULTS: The overexpression rates of GST-pi and PCNA were significantly higher in maxillary sinus SCC than in benign maxillary tumor and normal nasal mucosa (74.1% vs. 89.6% and 15.0%, P<0.01; 79.6% vs. 3.4% and 0, P<0.01). The 5-year survival rate was significantly higher in advanced maxillary sinus SCC patients with high expression of GST-pi than in the patients with low expression of GST-pi (34.5% vs. 21.2%, P=0.025); the difference between the patients with high and low expression of PCNA was not significant (18.0% vs. 27.0%, P=0.890). The expression of GST-pi was an independent prognostic factor of advanced maxillary sinus SCC (P=0.039, odds ratio>1). CONCLUSION: The overexpression of GST-pi is an independent prognostic factor of advanced maxillary sinus SCC, but that of PCNA isn't.

AB - BACKGROUND & OBJECTIVE: Tumor markers which relate to cell proliferation and metabolism have seldom been studied in maxillary sinus cancer. This study was conducted to identify the correlation of glutathione S-transferase pi (GST-pi) and proliferating cell nuclear antigen (PCNA) expression to prognosis of advanced maxillary sinus squamous cell carcinoma (SCC). METHODS: The expression of GST-pi and PCNA in 54 specimens of maxillary sinus SCC, 29 specimens of benign maxillary tumor, and 20 specimens of normal nasal mucosa was detected by immunohistochemistry. The correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus SCC was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model. RESULTS: The overexpression rates of GST-pi and PCNA were significantly higher in maxillary sinus SCC than in benign maxillary tumor and normal nasal mucosa (74.1% vs. 89.6% and 15.0%, P<0.01; 79.6% vs. 3.4% and 0, P<0.01). The 5-year survival rate was significantly higher in advanced maxillary sinus SCC patients with high expression of GST-pi than in the patients with low expression of GST-pi (34.5% vs. 21.2%, P=0.025); the difference between the patients with high and low expression of PCNA was not significant (18.0% vs. 27.0%, P=0.890). The expression of GST-pi was an independent prognostic factor of advanced maxillary sinus SCC (P=0.039, odds ratio>1). CONCLUSION: The overexpression of GST-pi is an independent prognostic factor of advanced maxillary sinus SCC, but that of PCNA isn't.

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SN - 1000-467X

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