Cortical surface area rather than cortical thickness potentially differentiates radiation encephalopathy at early stage in patients with nasopharyngeal carcinoma

You Ming Zhang, Ming Na Chen, Xiao Ping Yi, Li Li, Jian Ming Gao, Jin Lei Zhang, Xin Ru Yuan, Na Zhang, Li Zhi Liu, Pei Qiang Cai, Bihong T. Chen, Chishing Zee, Wei Hua Liao, Yuan Chao Zhang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Radiation encephalopathy (RE) is one of the most severe complications in nasopharyngeal carcinoma (NPC) patients after radiotherapy (RT). However, the morphological alteration of early RE is insufficiently investigated. We aimed to investigate the cortical thickness and surface area alterations in NPC patients with or without RE in the follow-up. A total of 168 NPC patients each underwent a single scan and analysis at various times either Pre-RT (n = 56) or Post-RT (n = 112). We further divided the Post-RT NPC patients into three groups based on the time of the analysis following RT (Post-RT within 6 months and Post-RT7-12 months) or whether RE signs were detected in the analysis (Post-RT RE proved in follow-up ). We confined the vertex-wise analyses of the cortical thickness and surface area to the bilateral temporal lobes. Interestingly, we revealed a gradual increase in the cortical surface area of the temporal lobe with increasing time after RT within the Post-RT RE proved in follow-up group, consistent with the between-group findings, which showed a significant increase in cortical surface area in the Post-RT RE proved in follow-up group relative to the Pre-RT group and the Post-RT within 6 months group. By contrast, such a trend was not observed in the cortical thickness findings. We concluded that the cortical surface area, rather than cortical thickness, may serve as a potential biomarker for early diagnosis of RE.

Original languageEnglish (US)
Article number599
JournalFrontiers in Neuroscience
Volume12
Issue numberAUG
DOIs
StatePublished - Aug 27 2018

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Brain Diseases
Radiotherapy
Radiation
Temporal Lobe
Nasopharyngeal carcinoma
Early Diagnosis
Biomarkers

Keywords

  • Cortical surface area
  • Cortical thickness
  • Nasopharyngeal carcinoma
  • Radiation encephalopathy
  • Structural MRI

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cortical surface area rather than cortical thickness potentially differentiates radiation encephalopathy at early stage in patients with nasopharyngeal carcinoma. / Zhang, You Ming; Chen, Ming Na; Yi, Xiao Ping; Li, Li; Gao, Jian Ming; Zhang, Jin Lei; Yuan, Xin Ru; Zhang, Na; Liu, Li Zhi; Cai, Pei Qiang; Chen, Bihong T.; Zee, Chishing; Liao, Wei Hua; Zhang, Yuan Chao.

In: Frontiers in Neuroscience, Vol. 12, No. AUG, 599, 27.08.2018.

Research output: Contribution to journalArticle

Zhang, YM, Chen, MN, Yi, XP, Li, L, Gao, JM, Zhang, JL, Yuan, XR, Zhang, N, Liu, LZ, Cai, PQ, Chen, BT, Zee, C, Liao, WH & Zhang, YC 2018, 'Cortical surface area rather than cortical thickness potentially differentiates radiation encephalopathy at early stage in patients with nasopharyngeal carcinoma', Frontiers in Neuroscience, vol. 12, no. AUG, 599. https://doi.org/10.3389/fnins.2018.00599
Zhang, You Ming ; Chen, Ming Na ; Yi, Xiao Ping ; Li, Li ; Gao, Jian Ming ; Zhang, Jin Lei ; Yuan, Xin Ru ; Zhang, Na ; Liu, Li Zhi ; Cai, Pei Qiang ; Chen, Bihong T. ; Zee, Chishing ; Liao, Wei Hua ; Zhang, Yuan Chao. / Cortical surface area rather than cortical thickness potentially differentiates radiation encephalopathy at early stage in patients with nasopharyngeal carcinoma. In: Frontiers in Neuroscience. 2018 ; Vol. 12, No. AUG.
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AU - Gao, Jian Ming

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AU - Zhang, Na

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AB - Radiation encephalopathy (RE) is one of the most severe complications in nasopharyngeal carcinoma (NPC) patients after radiotherapy (RT). However, the morphological alteration of early RE is insufficiently investigated. We aimed to investigate the cortical thickness and surface area alterations in NPC patients with or without RE in the follow-up. A total of 168 NPC patients each underwent a single scan and analysis at various times either Pre-RT (n = 56) or Post-RT (n = 112). We further divided the Post-RT NPC patients into three groups based on the time of the analysis following RT (Post-RT within 6 months and Post-RT7-12 months) or whether RE signs were detected in the analysis (Post-RT RE proved in follow-up ). We confined the vertex-wise analyses of the cortical thickness and surface area to the bilateral temporal lobes. Interestingly, we revealed a gradual increase in the cortical surface area of the temporal lobe with increasing time after RT within the Post-RT RE proved in follow-up group, consistent with the between-group findings, which showed a significant increase in cortical surface area in the Post-RT RE proved in follow-up group relative to the Pre-RT group and the Post-RT within 6 months group. By contrast, such a trend was not observed in the cortical thickness findings. We concluded that the cortical surface area, rather than cortical thickness, may serve as a potential biomarker for early diagnosis of RE.

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