Covariate-Adjusted Adaptive Dose-Finding: Early Phase Clinical Trials

Peter F. Thall; Hoang Q. Nguyen

doi:10.1201/9781351110273-130001059

Covariate-Adjusted Adaptive Dose-Finding: Early Phase Clinical Trials

Peter F. Thall
, Hoang Q. Nguyen

Biostatistics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Most methods for sequentially adaptive dose-finding in phase I clinical trials characterize outcome as an indicator yt of toxicity and assume that patients are homogeneous. This entry reviews a new method which requires an informative prior on covariate effect parameters, obtained from historical data.

Original language	English (US)
Title of host publication	Encyclopedia of Biopharmaceutical Statistics - Four Volume Set
Publisher	CRC Press
Pages	760-771
Number of pages	12
Volume	1-4
ISBN (Electronic)	9781351110266
ISBN (Print)	9781351110259
DOIs	https://doi.org/10.1201/9781351110273-130001059
State	Published - Jan 1 2018

Keywords

Adaptive design
Bayesian design
Individualized treatment
Phase I clinical trial
Phase I/II clinical trial.

ASJC Scopus subject areas

General Medicine
General Mathematics
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General Pharmacology, Toxicology and Pharmaceutics

Access to Document

10.1201/9781351110273-130001059

Cite this

@inbook{db7edcbefb4a4a49b62c62af3f335dcf,

title = "Covariate-Adjusted Adaptive Dose-Finding: Early Phase Clinical Trials",

abstract = "Most methods for sequentially adaptive dose-finding in phase I clinical trials characterize outcome as an indicator yt of toxicity and assume that patients are homogeneous. This entry reviews a new method which requires an informative prior on covariate effect parameters, obtained from historical data.",

keywords = "Adaptive design, Bayesian design, Individualized treatment, Phase I clinical trial, Phase I/II clinical trial.",

author = "Thall, \{Peter F.\} and Nguyen, \{Hoang Q.\}",

note = "Publisher Copyright: {\textcopyright} 2018 by Taylor \& Francis Group, LLC.",

year = "2018",

month = jan,

day = "1",

doi = "10.1201/9781351110273-130001059",

language = "English (US)",

isbn = "9781351110259",

volume = "1-4",

pages = "760--771",

booktitle = "Encyclopedia of Biopharmaceutical Statistics - Four Volume Set",

publisher = "CRC Press",

}

TY - CHAP

T1 - Covariate-Adjusted Adaptive Dose-Finding

T2 - Early Phase Clinical Trials

AU - Thall, Peter F.

AU - Nguyen, Hoang Q.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Most methods for sequentially adaptive dose-finding in phase I clinical trials characterize outcome as an indicator yt of toxicity and assume that patients are homogeneous. This entry reviews a new method which requires an informative prior on covariate effect parameters, obtained from historical data.

AB - Most methods for sequentially adaptive dose-finding in phase I clinical trials characterize outcome as an indicator yt of toxicity and assume that patients are homogeneous. This entry reviews a new method which requires an informative prior on covariate effect parameters, obtained from historical data.

KW - Adaptive design

KW - Bayesian design

KW - Individualized treatment

KW - Phase I clinical trial

KW - Phase I/II clinical trial.

UR - https://www.scopus.com/pages/publications/105043966014

UR - https://www.scopus.com/pages/publications/105043966014#tab=citedBy

U2 - 10.1201/9781351110273-130001059

DO - 10.1201/9781351110273-130001059

M3 - Chapter

AN - SCOPUS:105043966014

SN - 9781351110259

VL - 1-4

SP - 760

EP - 771

BT - Encyclopedia of Biopharmaceutical Statistics - Four Volume Set

PB - CRC Press

ER -

Covariate-Adjusted Adaptive Dose-Finding: Early Phase Clinical Trials

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this