CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK1 lymphoma after transplantation

Soumya Sundara Rajan; Lingxiao Li; Mercedes F. Kweh; Kranthi Kunkalla; Amit Dipak Amin; Nitin K. Agarwal; Francisco Vega; Jonathan H. Schatz

doi:10.1182/bloodadvances.2018025247

CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK¹ lymphoma after transplantation

Soumya Sundara Rajan, Lingxiao Li, Mercedes F. Kweh, Kranthi Kunkalla, Amit Dipak Amin, Nitin K. Agarwal, Francisco Vega, Jonathan H. Schatz

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Original language	English (US)
Pages (from-to)	1788-1794
Number of pages	7
Journal	Blood Advances
Volume	3
Issue number	12
DOIs	https://doi.org/10.1182/bloodadvances.2018025247
State	Published - 2019
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1182/bloodadvances.2018025247

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@article{8e47668b5edd46fda3caaf8ddb849e6f,

title = "CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK1 lymphoma after transplantation",

author = "Rajan, {Soumya Sundara} and Lingxiao Li and Kweh, {Mercedes F.} and Kranthi Kunkalla and Amin, {Amit Dipak} and Agarwal, {Nitin K.} and Francisco Vega and Schatz, {Jonathan H.}",

note = "Funding Information: This work was supported by National Institutes of Health, National Cancer Institute grant 1R01CA190696-01 (J.H.S.). Funding Information: The authors thank the Sheila and David Fuente Graduate Program in Cancer Biology at the University of Miami and are extremely grateful to Andrea Ventura (Memorial Sloan Kettering Cancer Center, New York, NY) and Danilo Maddalo (Novartis) for providing the sgNpm-Alk plasmid. The authors thank Mingjiang Xu (University of Miami) for developing the pathology core and helping with the slides for H&E staining and IHC, and as well as the laboratory of Feng-Chun Yang (University of Miami) for extensive use of the microscope camera. This work was supported by National Institutes of Health, National Cancer Institute grant 1R01CA190696-01 (J.H.S.).",

year = "2019",

doi = "10.1182/bloodadvances.2018025247",

language = "English (US)",

volume = "3",

pages = "1788--1794",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

number = "12",

}

TY - JOUR

T1 - CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK1 lymphoma after transplantation

AU - Rajan, Soumya Sundara

AU - Li, Lingxiao

AU - Kweh, Mercedes F.

AU - Kunkalla, Kranthi

AU - Amin, Amit Dipak

AU - Agarwal, Nitin K.

AU - Vega, Francisco

AU - Schatz, Jonathan H.

N1 - Funding Information: This work was supported by National Institutes of Health, National Cancer Institute grant 1R01CA190696-01 (J.H.S.). Funding Information: The authors thank the Sheila and David Fuente Graduate Program in Cancer Biology at the University of Miami and are extremely grateful to Andrea Ventura (Memorial Sloan Kettering Cancer Center, New York, NY) and Danilo Maddalo (Novartis) for providing the sgNpm-Alk plasmid. The authors thank Mingjiang Xu (University of Miami) for developing the pathology core and helping with the slides for H&E staining and IHC, and as well as the laboratory of Feng-Chun Yang (University of Miami) for extensive use of the microscope camera. This work was supported by National Institutes of Health, National Cancer Institute grant 1R01CA190696-01 (J.H.S.).

PY - 2019

Y1 - 2019

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UR - http://www.scopus.com/inward/citedby.url?scp=85068918760&partnerID=8YFLogxK

U2 - 10.1182/bloodadvances.2018025247

DO - 10.1182/bloodadvances.2018025247

M3 - Review article

C2 - 31189527

AN - SCOPUS:85068918760

SN - 2473-9529

VL - 3

SP - 1788

EP - 1794

JO - Blood Advances

JF - Blood Advances

IS - 12

ER -

CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK1 lymphoma after transplantation

ASJC Scopus subject areas

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CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK¹ lymphoma after transplantation