Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH

Samit Guha, Gillian Karen Shaw, Trevor M. Mitcham, Richard R. Bouchard, Bradley D. Smith

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalChemical Communications
Volume52
Issue number1
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

MD Anderson CCSG core facilities

  • Research Animal Support Facility
  • Small Animal Imaging Facility

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