Crystal structure of the endogenous agonist-bound prostanoid receptor EP3

Kazushi Morimoto, Ryoji Suno, Yunhong Hotta, Keitaro Yamashita, Kunio Hirata, Masaki Yamamoto, Shuh Narumiya, So Iwata, Takuya Kobayashi

Research output: Contribution to journalArticle

Abstract

Prostanoids are a series of bioactive lipid metabolites that function in an autacoid manner via activation of cognate G-protein-coupled receptors (GPCRs). Here, we report the crystal structure of human prostaglandin (PG) E receptor subtype EP3 bound to endogenous ligand PGE 2 at 2.90 Å resolution. The structure reveals important insights into the activation mechanism of prostanoid receptors and provides a molecular basis for the binding modes of endogenous ligands.

Original languageEnglish (US)
Pages (from-to)8-10
Number of pages3
JournalNature Chemical Biology
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2019

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Receptors, Prostaglandin E, EP3 Subtype
Prostaglandins
Autacoids
Ligands
G-Protein-Coupled Receptors
Prostaglandins E
Lipids

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Morimoto, K., Suno, R., Hotta, Y., Yamashita, K., Hirata, K., Yamamoto, M., ... Kobayashi, T. (2019). Crystal structure of the endogenous agonist-bound prostanoid receptor EP3. Nature Chemical Biology, 15(1), 8-10. https://doi.org/10.1038/s41589-018-0171-8

Crystal structure of the endogenous agonist-bound prostanoid receptor EP3. / Morimoto, Kazushi; Suno, Ryoji; Hotta, Yunhong; Yamashita, Keitaro; Hirata, Kunio; Yamamoto, Masaki; Narumiya, Shuh; Iwata, So; Kobayashi, Takuya.

In: Nature Chemical Biology, Vol. 15, No. 1, 01.01.2019, p. 8-10.

Research output: Contribution to journalArticle

Morimoto, K, Suno, R, Hotta, Y, Yamashita, K, Hirata, K, Yamamoto, M, Narumiya, S, Iwata, S & Kobayashi, T 2019, 'Crystal structure of the endogenous agonist-bound prostanoid receptor EP3' Nature Chemical Biology, vol. 15, no. 1, pp. 8-10. https://doi.org/10.1038/s41589-018-0171-8
Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M et al. Crystal structure of the endogenous agonist-bound prostanoid receptor EP3. Nature Chemical Biology. 2019 Jan 1;15(1):8-10. https://doi.org/10.1038/s41589-018-0171-8
Morimoto, Kazushi ; Suno, Ryoji ; Hotta, Yunhong ; Yamashita, Keitaro ; Hirata, Kunio ; Yamamoto, Masaki ; Narumiya, Shuh ; Iwata, So ; Kobayashi, Takuya. / Crystal structure of the endogenous agonist-bound prostanoid receptor EP3. In: Nature Chemical Biology. 2019 ; Vol. 15, No. 1. pp. 8-10.
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