CT guided radioactive 125I seed implantation in treating localized advanced pulmonary carcinoma

Fu Jun Zhang, Chuan Xing Li, Pei Hong Wu, Yue Xia Wu, De Chao Jiao, Jian Liu, Yu Liang Li

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    Objective: To investigate the clinical value of CT guided radioactive 125I seed implantation (CTRISI) in the treatment of localized advanced pulmonary carcinoma. Methods: Thirty-two biopsy -confirmed localized advanced pulmonary carcinoma patients (Group A) with 48 lesions, 5.5 (4.5-7.5) cm in diameter, clearly demarcated from the adjacent normal tissue, who failed to be improved in the first line chemotherapy, underwent CI-guided implantation of 125I seeds of 23.3-30.0 megabecquerel (MBq) into these lesions with the matched peripheral dose of 100-150 Gy. Thirty patients (Group B) treated by first line chemotherapy were randomly selected as the control group. Results: CT follow-up two months later proved that the local control rate of Group A was 78.1%, significantly higher than that of Group B; the one year survival rate of Group A was 65.0%, significantly higher than that of Group B (48.0%); the median survival time of Group A was 15 months, significantly longer than that of Group B (11 months); no myelosuppression was found in Group, and the myelosuppression rate of Group B was 46.3%. In Group A small amount of effusion was observed, pneumothorax occurred in 4 cases with one of the lungs compressed by less than 30% that was improved after conservative treatment; one week after the procedure bloody sputum occurred in 15 cases. Conclusion: Improving the living quality obviously and with good short-term effects and few complications, CTGRISI procedure is safe and well-tolerated in treating localized advanced pulmonary carcinoma in Chinese patients.

    Original languageEnglish (US)
    Pages (from-to)3272-3275
    Number of pages4
    JournalNational Medical Journal of China
    Volume87
    Issue number46
    StatePublished - Dec 11 2007

    Keywords

    • Evaluation studies
    • Iodine radioisotopes
    • Lung neoplasms
    • Radiology, interventional

    ASJC Scopus subject areas

    • Medicine(all)

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    Zhang, F. J., Li, C. X., Wu, P. H., Wu, Y. X., Jiao, D. C., Liu, J., & Li, Y. L. (2007). CT guided radioactive 125I seed implantation in treating localized advanced pulmonary carcinoma. National Medical Journal of China, 87(46), 3272-3275.