TY - JOUR
T1 - Current Concepts in Capsular Contracture
T2 - Pathophysiology, Prevention, and Management
AU - Safran, Tyler
AU - Nepon, Hillary
AU - Chu, Carrie K.
AU - Winocour, Sebastian
AU - Murphy, Amanda M.
AU - Davison, Peter G.
AU - Dionisopolos, Tassos
AU - Vorstenbosch, Joshua
N1 - Publisher Copyright:
© 2021 Thieme Medical Publishers, Inc.. All rights reserved.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Over 400,000 women in the United States alone will have breast implant surgery each year. Although capsular contracture represents the most common complication of breast implant surgery, surgeons continue to debate the precise etiology. General agreement exists concerning the inflammatory origin of capsular fibrosis, but the inciting events triggering the inflammatory cascade appear to be multifactorial, making it difficult to predict why one patient may develop capsular contracture while another will not. Accordingly, researchers have explored many different surgical, biomaterial, and medical therapies to address these multiple factors in an attempt to prevent and treat capsular contracture. In the current paper, we aim to inform the reader on the most up-to-date understanding of the pathophysiology, prevention, and treatment of capsular contracture.
AB - Over 400,000 women in the United States alone will have breast implant surgery each year. Although capsular contracture represents the most common complication of breast implant surgery, surgeons continue to debate the precise etiology. General agreement exists concerning the inflammatory origin of capsular fibrosis, but the inciting events triggering the inflammatory cascade appear to be multifactorial, making it difficult to predict why one patient may develop capsular contracture while another will not. Accordingly, researchers have explored many different surgical, biomaterial, and medical therapies to address these multiple factors in an attempt to prevent and treat capsular contracture. In the current paper, we aim to inform the reader on the most up-to-date understanding of the pathophysiology, prevention, and treatment of capsular contracture.
KW - breast implant
KW - capsular contracture
KW - foreign body reaction
KW - inflammation
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UR - http://www.scopus.com/inward/citedby.url?scp=85110414644&partnerID=8YFLogxK
U2 - 10.1055/s-0041-1731793
DO - 10.1055/s-0041-1731793
M3 - Review article
C2 - 34526867
AN - SCOPUS:85110414644
SN - 1535-2188
VL - 35
SP - 189
EP - 197
JO - Seminars in Plastic Surgery
JF - Seminars in Plastic Surgery
IS - 3
ER -