Current Role of Radiation Therapy in the Management of Malignant Central Nervous System Tumors

Ahsan Farooqi; Jing Li; John de Groot; Debra Nana Yeboa

doi:10.1016/j.hoc.2019.08.015

Current Role of Radiation Therapy in the Management of Malignant Central Nervous System Tumors

Ahsan Farooqi, Jing Li, John de Groot, Debra Nana Yeboa

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The 2016 World Health Organization classification of central nervous system (CNS) tumors underwent significant restructuring and for the first time gliomas are classified according to both molecular and histologic parameters which guides glioma management. Radiation for intermediate-risk meningiomas improves the progression-free survival from historical controls, and studies are ongoing for atypical meningiomas. For brain metastases, use of stereotactic radiosurgery for a higher number of lesions has become clinical practice. Additionally, hippocampal-sparing whole brain radiation shows promise in preserving neuro-cognitive function. This article summarizes the evolving role of radiation therapy in the management of malignant CNS neoplasms.

Original language	English (US)
Pages (from-to)	13-28
Number of pages	16
Journal	Hematology/Oncology Clinics of North America
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.hoc.2019.08.015
State	Published - Feb 2020

Keywords

Brain metastases
Central nervous system brain tumors
Clinical review
Glioma
Meningioma
Radiation therapy

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2019.08.015

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title = "Current Role of Radiation Therapy in the Management of Malignant Central Nervous System Tumors",

abstract = "The 2016 World Health Organization classification of central nervous system (CNS) tumors underwent significant restructuring and for the first time gliomas are classified according to both molecular and histologic parameters which guides glioma management. Radiation for intermediate-risk meningiomas improves the progression-free survival from historical controls, and studies are ongoing for atypical meningiomas. For brain metastases, use of stereotactic radiosurgery for a higher number of lesions has become clinical practice. Additionally, hippocampal-sparing whole brain radiation shows promise in preserving neuro-cognitive function. This article summarizes the evolving role of radiation therapy in the management of malignant CNS neoplasms.",

keywords = "Brain metastases, Central nervous system brain tumors, Clinical review, Glioma, Meningioma, Radiation therapy",

author = "Ahsan Farooqi and Jing Li and {de Groot}, John and Yeboa, {Debra Nana}",

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AU - Li, Jing

AU - de Groot, John

AU - Yeboa, Debra Nana

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AB - The 2016 World Health Organization classification of central nervous system (CNS) tumors underwent significant restructuring and for the first time gliomas are classified according to both molecular and histologic parameters which guides glioma management. Radiation for intermediate-risk meningiomas improves the progression-free survival from historical controls, and studies are ongoing for atypical meningiomas. For brain metastases, use of stereotactic radiosurgery for a higher number of lesions has become clinical practice. Additionally, hippocampal-sparing whole brain radiation shows promise in preserving neuro-cognitive function. This article summarizes the evolving role of radiation therapy in the management of malignant CNS neoplasms.

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KW - Central nervous system brain tumors

KW - Clinical review

KW - Glioma

KW - Meningioma

KW - Radiation therapy

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Current Role of Radiation Therapy in the Management of Malignant Central Nervous System Tumors

Abstract

Keywords

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