Current therapeutic options for low-risk papillary thyroid carcinoma: Scoping evidence review

Alvaro Sanabria, Pilar Pinillos, Renan B. Lira, Jatin P. Shah, Ralph P. Tufano, Mark E. Zafereo, Iain J. Nixon, Gregory W. Randolph, Ricard Simo, Vincent Vander Poorten, Alessandra Rinaldo, Jesus E. Medina, Avi Khafif, Peter Angelos, Antti A. Mäkitie, Ashok R. Shaha, Juan P. Rodrigo, Dana M. Hartl, Luiz P. Kowalski, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Most cases of thyroid carcinoma are classified as low risk. These lesions have been treated with open surgery, remote access thyroidectomy, active surveillance, and percutaneous ablation. However, there is lack of consensus and clear indications for a specific treatment selection. The objective of this study is to review the literature regarding the indications for management selection for low-risk carcinomas. Systematic review exploring inclusion and exclusion criteria used to select patients with low-risk carcinomas for treatment approaches. The search found 69 studies. The inclusion criteria most reported were nodule diameter and histopathological confirmation of the tumor type. The most common exclusions were lymph node metastasis and extra-thyroidal extension. There was significant heterogeneity among inclusion and exclusion criteria according to the analyzed therapeutic approach. Alternative therapeutic approaches in low-risk carcinomas can be cautiously considered. Open thyroidectomy remains the standard treatment against which all other approaches must be compared.

Original languageEnglish (US)
Pages (from-to)226-237
Number of pages12
JournalHead and Neck
Issue number1
StatePublished - Jan 2022
Externally publishedYes


  • ablation
  • papillary carcinoma
  • surgery
  • surveillance
  • thyroid carcinoma
  • treatment

ASJC Scopus subject areas

  • Otorhinolaryngology


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