Cutaneous angiosarcoma: A current update

Elina Shustef, Viktoryia Kazlouskaya, Victor G. Prieto, Doina Ivan, Phyu P. Aung

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

Cutaneous angiosarcoma (cAS) is a rare malignant neoplasm with variable clinical presentation. Although a distinct vascular tumour, cAS shares many overlapping histopathological features with other vasoformative and epithelioid tumours or 'mimickers'. cAS shows aggressive behaviour and carries a grave prognosis, thus early diagnosis is of paramount importance to achieve the best possible outcomes. Recently, several genetic studies were conducted leading to the identification of novel molecular targets in the treatment of cAS. Herein, we present a comprehensive review of cAS with discussion of its clinical, histopathological and molecular aspects, the differential diagnosis, as well as current therapies including ongoing clinical trials.

Original languageEnglish (US)
Pages (from-to)917-925
Number of pages9
JournalJournal of Clinical Pathology
Volume70
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • angiosarcoma
  • cutaneous vascular lesions
  • histologic mimickers
  • histopathology
  • immunohistochemistry
  • molecular and therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint

Dive into the research topics of 'Cutaneous angiosarcoma: A current update'. Together they form a unique fingerprint.

Cite this