TY - JOUR
T1 - Cutaneous angiosarcoma
T2 - A current update
AU - Shustef, Elina
AU - Kazlouskaya, Viktoryia
AU - Prieto, Victor G.
AU - Ivan, Doina
AU - Aung, Phyu P.
N1 - Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - Cutaneous angiosarcoma (cAS) is a rare malignant neoplasm with variable clinical presentation. Although a distinct vascular tumour, cAS shares many overlapping histopathological features with other vasoformative and epithelioid tumours or 'mimickers'. cAS shows aggressive behaviour and carries a grave prognosis, thus early diagnosis is of paramount importance to achieve the best possible outcomes. Recently, several genetic studies were conducted leading to the identification of novel molecular targets in the treatment of cAS. Herein, we present a comprehensive review of cAS with discussion of its clinical, histopathological and molecular aspects, the differential diagnosis, as well as current therapies including ongoing clinical trials.
AB - Cutaneous angiosarcoma (cAS) is a rare malignant neoplasm with variable clinical presentation. Although a distinct vascular tumour, cAS shares many overlapping histopathological features with other vasoformative and epithelioid tumours or 'mimickers'. cAS shows aggressive behaviour and carries a grave prognosis, thus early diagnosis is of paramount importance to achieve the best possible outcomes. Recently, several genetic studies were conducted leading to the identification of novel molecular targets in the treatment of cAS. Herein, we present a comprehensive review of cAS with discussion of its clinical, histopathological and molecular aspects, the differential diagnosis, as well as current therapies including ongoing clinical trials.
KW - angiosarcoma
KW - cutaneous vascular lesions
KW - histologic mimickers
KW - histopathology
KW - immunohistochemistry
KW - molecular and therapy
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U2 - 10.1136/jclinpath-2017-204601
DO - 10.1136/jclinpath-2017-204601
M3 - Review article
C2 - 28916596
AN - SCOPUS:85032581451
SN - 0021-9746
VL - 70
SP - 917
EP - 925
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
IS - 11
ER -