Abstract
Merkel cell polyomavirus (MCPyV), trichodysplasia spinulosa-associated polyomavirus (TSPyV), human polyomavirus 6 (HPyV6), and human polyomavirus 7 (HPyV7) are implicated in the pathogeneses of distinct hyperproliferative cutaneous growths and encode small tumor (sT) antigens. The current study demonstrates that the four sT antigens differentially regulate 4E-binding protein 1 (4E-BP1) serine 65 hyperphosphorylation. MCPyV and HPyV7 sT antigens were found to promote the presence of the hyperphosphorylated 4E-BP1-δ isoform, while TSPyV and HPyV6 sT antigens had no significant effects. Given that hyperphosphorylated 4E-BP1 is associated with an aggressive cancer phenotype, our findings confirm the previously reported pathogenicity of MCPyV sT and highlight a novel mechanism by which HPyV7 sT may mediate oncogenesis.
Original language | English (US) |
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Pages (from-to) | 382-385 |
Number of pages | 4 |
Journal | Intervirology |
Volume | 58 |
Issue number | 6 |
DOIs | |
State | Published - May 1 2016 |
Externally published | Yes |
Keywords
- 4E-binding protein 1
- Human polyomavirus
- Human polyomavirus 6
- Human polyomavirus 7
- Merkel cell polyomavirus
- Small T antigen
- Trichodysplasia spinulosa-associated polyomavirus
ASJC Scopus subject areas
- Virology
- Infectious Diseases