Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma

Primary cutaneous lymphomas comprise a group of nonHodgkin lymphomas that occur primarily in the skin and are characterized by heterogeneous clinical, pathological, immunological, and molecular features. Mycosis fungoides and Sézary syndrome are the most common subtypes of all primary cutaneous lymphomas followed by CD30+ T cell lymphoproliferative disorder. Staging and appropriate work-up are critical for an optimal treatment plan that includes skin-directed and/or systemic regimens. Advances in biology including tumor microenvironment and molecular mechanisms of these rare entities may assist in the development of new immune therapies providing promising treatment approaches tailored for patients with relapse/refractory disease.