TY - JOUR
T1 - Cutting edge
T2 - A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction
AU - Liu, Xikui
AU - Alexiou, Maria
AU - Martin-Orozco, Natalia
AU - Chung, Yeonseok
AU - Nurieva, Roza I.
AU - Ma, Li
AU - Tian, Qiang
AU - Kollias, George
AU - Lu, Sijie
AU - Graf, Daniel
AU - Dong, Chen
PY - 2009/4/15
Y1 - 2009/4/15
N2 - T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed. In this study, we generated a novel strain of BTLA-deficient mice and used three different models to characterize the function of BTLA in controlling T cell tolerance. In an oral tolerance model, BTLA-deficient mice were found resistant to the induction of T cell tolerance to an oral Ag. Moreover, compared with wild-type OT-II cells, BTLA-/- OT-II cells were less susceptible to tolerance induction by a high-dose OVA peptide administered i.v. Finally, BTLA-/- OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo.
AB - T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed. In this study, we generated a novel strain of BTLA-deficient mice and used three different models to characterize the function of BTLA in controlling T cell tolerance. In an oral tolerance model, BTLA-deficient mice were found resistant to the induction of T cell tolerance to an oral Ag. Moreover, compared with wild-type OT-II cells, BTLA-/- OT-II cells were less susceptible to tolerance induction by a high-dose OVA peptide administered i.v. Finally, BTLA-/- OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo.
UR - http://www.scopus.com/inward/record.url?scp=65249168307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65249168307&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.0803161
DO - 10.4049/jimmunol.0803161
M3 - Article
C2 - 19342624
AN - SCOPUS:65249168307
SN - 0022-1767
VL - 182
SP - 4516
EP - 4520
JO - Journal of Immunology
JF - Journal of Immunology
IS - 8
ER -