CYP enzyme system and its relevance to the pharmacology of sleep

Inna D’Empaire; Sheldon H. Preskorn

CYP enzyme system and its relevance to the pharmacology of sleep

Inna D’Empaire
, Sheldon H. Preskorn

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The cytochrome P450 (CYP) enzyme system is a major determinant of the clearance of the vast majority of drugs. As such, it determines the magnitude and duration of the effects of most drugs, which is relevant to the pharmacology of sleep in two ways: • Alterations in either the magnitude or the duration of effects of sedative-hypnotic (S-H) drugs will determine their efficacy, toxicity/tolerability, and/or cumulative effects, and potentially the risk of withdrawal symptoms.

Original language	English (US)
Title of host publication	Sleep Disorders
Subtitle of host publication	Diagnosis and Therapeutics
Publisher	CRC Press
Pages	133-139
Number of pages	7
ISBN (Electronic)	9780203091715
ISBN (Print)	9780415438186
State	Published - Jan 1 2008
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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CYP enzyme system and its relevance to the pharmacology of sleep

Abstract

ASJC Scopus subject areas

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