Cytogenetic analysis of telomere dysfunction.

Asha S. Multani; Sandy Chang

doi:10.1007/978-1-61779-092-8_13

Cytogenetic analysis of telomere dysfunction.

Asha S. Multani
, Sandy Chang

Genetics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Dysfunctional telomeres arising either through natural attrition due to telomerase deficiency or by the removal of telomere binding proteins are recognized as double stranded breaks (DSBs). Repair of DSBs is crucial for the maintenance of genome stability. In mammals, DSBs are repaired by either error prone nonhomologous end joining (NHEJ) or error free homologous recombination (HR) and can be visualized as chromosomal fusions.

Original language	English (US)
Pages (from-to)	139-143
Number of pages	5
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	735
DOIs	https://doi.org/10.1007/978-1-61779-092-8_13
State	Published - 2011

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/978-1-61779-092-8_13

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title = "Cytogenetic analysis of telomere dysfunction.",

abstract = "Dysfunctional telomeres arising either through natural attrition due to telomerase deficiency or by the removal of telomere binding proteins are recognized as double stranded breaks (DSBs). Repair of DSBs is crucial for the maintenance of genome stability. In mammals, DSBs are repaired by either error prone nonhomologous end joining (NHEJ) or error free homologous recombination (HR) and can be visualized as chromosomal fusions.",

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AB - Dysfunctional telomeres arising either through natural attrition due to telomerase deficiency or by the removal of telomere binding proteins are recognized as double stranded breaks (DSBs). Repair of DSBs is crucial for the maintenance of genome stability. In mammals, DSBs are repaired by either error prone nonhomologous end joining (NHEJ) or error free homologous recombination (HR) and can be visualized as chromosomal fusions.

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UR - https://www.scopus.com/pages/publications/79960979773#tab=citedBy

U2 - 10.1007/978-1-61779-092-8_13

DO - 10.1007/978-1-61779-092-8_13

M3 - Article

C2 - 21461818

AN - SCOPUS:79960979773

SN - 1064-3745

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JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

ER -

Cytogenetic analysis of telomere dysfunction.

Abstract

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