CYTOGENETIC DIAGNOSIS OF MALIGNANCY IN RECURRENT MENINGIOMA

William F. Benedict; Charles D. Brown; Ian H. Porter; Rudolfo A. Florentin

doi:10.1016/S0140-6736(70)91098-6

CYTOGENETIC DIAGNOSIS OF MALIGNANCY IN RECURRENT MENINGIOMA

William F. Benedict, Charles D. Brown, Ian H. Porter, Rudolfo A. Florentin

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Chromosome studies were done on a meningioma in which it was impossible to determine histologically whether or not the tumour was malignant. Eighty-four metaphases were studied and a mode of 38 chromosomes with 3 marker chromosomes was found. These findings suggested that the tumour was malignant. The tumour recurred 18 months later and was then confirmed histologically to be malignant. Cytogenetic analysis showed a similar chromosomal pattern although clonal evolution had occurred. It is felt that chromosome studies may be a useful supplement to histological examination when the question of malignancy is in doubt.

Original language	English (US)
Pages (from-to)	971-973
Number of pages	3
Journal	The Lancet
Volume	295
Issue number	7654
DOIs	https://doi.org/10.1016/S0140-6736(70)91098-6
State	Published - May 9 1970

ASJC Scopus subject areas

General Medicine

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title = "CYTOGENETIC DIAGNOSIS OF MALIGNANCY IN RECURRENT MENINGIOMA",

abstract = "Chromosome studies were done on a meningioma in which it was impossible to determine histologically whether or not the tumour was malignant. Eighty-four metaphases were studied and a mode of 38 chromosomes with 3 marker chromosomes was found. These findings suggested that the tumour was malignant. The tumour recurred 18 months later and was then confirmed histologically to be malignant. Cytogenetic analysis showed a similar chromosomal pattern although clonal evolution had occurred. It is felt that chromosome studies may be a useful supplement to histological examination when the question of malignancy is in doubt.",

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AU - Benedict, William F.

AU - Brown, Charles D.

AU - Porter, Ian H.

AU - Florentin, Rudolfo A.

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N2 - Chromosome studies were done on a meningioma in which it was impossible to determine histologically whether or not the tumour was malignant. Eighty-four metaphases were studied and a mode of 38 chromosomes with 3 marker chromosomes was found. These findings suggested that the tumour was malignant. The tumour recurred 18 months later and was then confirmed histologically to be malignant. Cytogenetic analysis showed a similar chromosomal pattern although clonal evolution had occurred. It is felt that chromosome studies may be a useful supplement to histological examination when the question of malignancy is in doubt.

AB - Chromosome studies were done on a meningioma in which it was impossible to determine histologically whether or not the tumour was malignant. Eighty-four metaphases were studied and a mode of 38 chromosomes with 3 marker chromosomes was found. These findings suggested that the tumour was malignant. The tumour recurred 18 months later and was then confirmed histologically to be malignant. Cytogenetic analysis showed a similar chromosomal pattern although clonal evolution had occurred. It is felt that chromosome studies may be a useful supplement to histological examination when the question of malignancy is in doubt.

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CYTOGENETIC DIAGNOSIS OF MALIGNANCY IN RECURRENT MENINGIOMA

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