TY - JOUR
T1 - Debate
T2 - Improvements in Systemic Therapies for Liver Metastases Will Increase the Role of Locoregional Treatments
AU - Kawaguchi, Yoshikuni
AU - De Bellis, Mario
AU - Panettieri, Elena
AU - Duwe, Gregor
AU - Vauthey, Jean Nicolas
N1 - Funding Information:
Grant support: This research was supported in part by the National Institutes of Health (T32 CA 009599) and the MD Anderson Cancer Center Support Grant, CA016672.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/1
Y1 - 2021/1
N2 - The benefit of resection of liver metastases depends on primary diseases. Neuroendocrine tumors are associated with favorable prognosis after resection of liver metastases. Gastric cancer has worse tumor biology, and resection of gastric liver metastases should be performed in selected patients. A multidisciplinary approach is well established for colorectal liver metastases (CLMs). Resection remains the only curative treatment of CLM. Chemotherapy and molecular-targeted therapy have improved survival in unresectable metastatic colorectal cancer. Understanding of the following two strategies, conversion therapy and two-stage hepatectomy, are important to make this patient group to be candidates for curative-intent surgery.
AB - The benefit of resection of liver metastases depends on primary diseases. Neuroendocrine tumors are associated with favorable prognosis after resection of liver metastases. Gastric cancer has worse tumor biology, and resection of gastric liver metastases should be performed in selected patients. A multidisciplinary approach is well established for colorectal liver metastases (CLMs). Resection remains the only curative treatment of CLM. Chemotherapy and molecular-targeted therapy have improved survival in unresectable metastatic colorectal cancer. Understanding of the following two strategies, conversion therapy and two-stage hepatectomy, are important to make this patient group to be candidates for curative-intent surgery.
KW - Chemotherapy
KW - Colorectal liver metastasis
KW - Conversion therapy
KW - Gastric liver metastasis
KW - Molecular-targeted therapy
KW - Neuroendocrine liver metastasis
KW - Resection
KW - Two-stage hepatectomy
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U2 - 10.1016/j.soc.2020.08.009
DO - 10.1016/j.soc.2020.08.009
M3 - Review article
C2 - 33220806
AN - SCOPUS:85094581445
SN - 1055-3207
VL - 30
SP - 205
EP - 218
JO - Surgical oncology clinics of North America
JF - Surgical oncology clinics of North America
IS - 1
ER -