Deciphering the binding mode of Zolpidem to GABA _A α ₁ receptor - Insights from molecular dynamics simulation

Keyphrases

• Molecular Dynamics Simulation 100%
• Binding Mode 100%
• GABAA 100%
• Zolpidem 100%
• 1 Receptor 100%
• Conformational Change 33%
• Vestibule 33%
• Simulation Study 16%
• Ligand-binding Domain 16%
• Drug Design 16%
• Selective Agonist 16%
• GABAA Receptor (GABAAR) 16%
• Agonist Binding 16%
• Benzodiazepine Binding Site 16%
• C-loop 16%
• Holo 16%
• Atomistic Molecular Dynamics Simulations 16%
• Sway 16%
• Energy Decomposition Analysis 16%
• AR Activity 16%

Biochemistry, Genetics and Molecular Biology

• Gamma-Aminobutyric Acid 100%
• Zolpidem 100%
• Agonist 33%
• Conformational Change 33%
• Motion 16%
• Binding Site 16%
• Ligand Binding Domain 16%
• Benzodiazepine 16%
• GABAA Receptor 16%
• Drug Development 16%