Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis

Priscilla McAuliffe; Funda Meric-Bernstam; Gordon Mills; Ana Gonzalez-Angulo

doi:10.3816/CBC.2010.s.013

Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis

Priscilla McAuliffe
, Funda Meric-Bernstam
, Gordon Mills
, Ana Gonzalez-Angulo

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression, and outcomes, including growth and proliferation, metabolism, motility, migration, invasion, angiogenesis, survival, and autophagy. Tight regulation of this pathway is paramount to ensure that multiple cellular inputs are integrated for appropriate cellular outcomes. Frequent deregulation and aberrations of this pathway have been implicated in breast cancer development and progression. This review focuses on the biology of this pathway and its role in breast cancer pathogenesis. The role of therapies directed at targeting mTOR in the PI3K/Akt/mTOR pathway, which are currently being evaluated in clinical trials, will also be reviewed.

Original language	English (US)
Pages (from-to)	S59-S65
Journal	Clinical breast cancer
Volume	10
Issue number	SUPPL. 3
DOIs	https://doi.org/10.3816/CBC.2010.s.013
State	Published - Nov 1 2010

Keywords

HER2
Mammalian target of rapamycin
PTEN
Phosphatidylinositol 3-kinase

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3816/CBC.2010.s.013

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title = "Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis",

abstract = "The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression, and outcomes, including growth and proliferation, metabolism, motility, migration, invasion, angiogenesis, survival, and autophagy. Tight regulation of this pathway is paramount to ensure that multiple cellular inputs are integrated for appropriate cellular outcomes. Frequent deregulation and aberrations of this pathway have been implicated in breast cancer development and progression. This review focuses on the biology of this pathway and its role in breast cancer pathogenesis. The role of therapies directed at targeting mTOR in the PI3K/Akt/mTOR pathway, which are currently being evaluated in clinical trials, will also be reviewed.",

keywords = "HER2, Mammalian target of rapamycin, PTEN, Phosphatidylinositol 3-kinase",

author = "Priscilla McAuliffe and Funda Meric-Bernstam and Gordon Mills and Ana Gonzalez-Angulo",

note = "Funding Information: Funding support was provided by AACR SU2C Dream Team to F. Meric-Bernstam, G.B. Mills, and Ana M. Gonzalez-Angulo; S T32 CA009599-22 to P.F. McAuliffe and F. Meric-Bernstam; and NCI 1K23CA121994-01 to Ana M. Gonzalez-Angulo.",

year = "2010",

month = nov,

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doi = "10.3816/CBC.2010.s.013",

language = "English (US)",

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AU - Meric-Bernstam, Funda

AU - Mills, Gordon

AU - Gonzalez-Angulo, Ana

N1 - Funding Information: Funding support was provided by AACR SU2C Dream Team to F. Meric-Bernstam, G.B. Mills, and Ana M. Gonzalez-Angulo; S T32 CA009599-22 to P.F. McAuliffe and F. Meric-Bernstam; and NCI 1K23CA121994-01 to Ana M. Gonzalez-Angulo.

PY - 2010/11/1

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N2 - The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression, and outcomes, including growth and proliferation, metabolism, motility, migration, invasion, angiogenesis, survival, and autophagy. Tight regulation of this pathway is paramount to ensure that multiple cellular inputs are integrated for appropriate cellular outcomes. Frequent deregulation and aberrations of this pathway have been implicated in breast cancer development and progression. This review focuses on the biology of this pathway and its role in breast cancer pathogenesis. The role of therapies directed at targeting mTOR in the PI3K/Akt/mTOR pathway, which are currently being evaluated in clinical trials, will also be reviewed.

AB - The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression, and outcomes, including growth and proliferation, metabolism, motility, migration, invasion, angiogenesis, survival, and autophagy. Tight regulation of this pathway is paramount to ensure that multiple cellular inputs are integrated for appropriate cellular outcomes. Frequent deregulation and aberrations of this pathway have been implicated in breast cancer development and progression. This review focuses on the biology of this pathway and its role in breast cancer pathogenesis. The role of therapies directed at targeting mTOR in the PI3K/Akt/mTOR pathway, which are currently being evaluated in clinical trials, will also be reviewed.

KW - HER2

KW - Mammalian target of rapamycin

KW - PTEN

KW - Phosphatidylinositol 3-kinase

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M3 - Article

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AN - SCOPUS:78649706942

SN - 1526-8209

VL - 10

SP - S59-S65

JO - Clinical breast cancer

JF - Clinical breast cancer

IS - SUPPL. 3

ER -

Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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