TY - JOUR
T1 - Decrease in the number of reported cases of zygomycosis among patients with diabetes mellitus
T2 - A hypothesis
AU - Kontoyiannis, Dimitrios P.
PY - 2007/4/15
Y1 - 2007/4/15
N2 - The number of reported cases of zygomycosis in patients with diabetes mellitus in developed countries has decreased since the 1990s, despite the rapid increase in the prevalence of diabetic patients in the Western world. Although prospective population-based studies need to better document this phenomenon, which may have a complex explanation, here I propose the hypothesis that widespread use of statins in patients with diabetes underlies such a trend. Statins have been shown to direct inhibitory activity against a range of Zygomycetes molds, both in vitro and in vivo.
AB - The number of reported cases of zygomycosis in patients with diabetes mellitus in developed countries has decreased since the 1990s, despite the rapid increase in the prevalence of diabetic patients in the Western world. Although prospective population-based studies need to better document this phenomenon, which may have a complex explanation, here I propose the hypothesis that widespread use of statins in patients with diabetes underlies such a trend. Statins have been shown to direct inhibitory activity against a range of Zygomycetes molds, both in vitro and in vivo.
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U2 - 10.1086/512817
DO - 10.1086/512817
M3 - Short survey
C2 - 17366455
AN - SCOPUS:33947536898
SN - 1058-4838
VL - 44
SP - 1089
EP - 1090
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 8
ER -