Deletion of lp36 as a Primary Chromosomal Aberration in Intestinal Tumorigenesis

Georgia Bardi, Nikos Pandis, Lilian Bomme, Sverre Heim

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Abstract

Cytogenetic analysis of short-term cultures from benign intestinal tumors revealed clonal chromosome aberrations in five colorectal adenomas, one adenoma of the papilla Vateri, and one hyperplastic polyp of the rectum. One adenoma had numerical aberrations only, but in all other tumors structural rearrangements were found that led to loss of genetic material from 1p. In three of the cases, the deletion was restricted to the 1p36 band; the rest had lost larger 1p segments. The rearrangement of chromosome 1 was the sole karyotypic anomaly in three adenomas, all with mild or moderate dysplasia, and in the hyperplastic polyp. Both adenomas that had additional aberrations beyond the lp loss showed severe dysplasia. We conclude that cytogenetically detectable loss of genetic information from lp36 is an early, seemingly primary, premalignant event in intestinal tumorigenesis. The fact that the adenomas with lp- as the sole change showed only mild or moderate dysplasia and that the del(lp) was found also in the hyperplastic polyp suggests that this aberration is more related to the induction of hyperproliferation than to dif-ferentiation disturbances in the intestinal mucosa.

Original languageEnglish (US)
Pages (from-to)1895-1898
Number of pages4
JournalCancer research
Volume53
Issue number8
StatePublished - Apr 1993

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Chromosome Aberrations
Adenoma
Carcinogenesis
Polyps
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Intestinal Mucosa
Rectum
Neoplasms
Genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Deletion of lp36 as a Primary Chromosomal Aberration in Intestinal Tumorigenesis. / Bardi, Georgia; Pandis, Nikos; Bomme, Lilian; Heim, Sverre.

In: Cancer research, Vol. 53, No. 8, 04.1993, p. 1895-1898.

Research output: Contribution to journalArticle

Bardi, G, Pandis, N, Bomme, L & Heim, S 1993, 'Deletion of lp36 as a Primary Chromosomal Aberration in Intestinal Tumorigenesis', Cancer research, vol. 53, no. 8, pp. 1895-1898.
Bardi, Georgia ; Pandis, Nikos ; Bomme, Lilian ; Heim, Sverre. / Deletion of lp36 as a Primary Chromosomal Aberration in Intestinal Tumorigenesis. In: Cancer research. 1993 ; Vol. 53, No. 8. pp. 1895-1898.
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