Deletions in a recombinant retrovirus genome associated with its expression in embryonal carcinoma cells

M. Taketo, D. J. Shaffer

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    We analyzed embryonal carcinoma cell lines infected with a recombinant Moloney murine leukemia virus. Lines that carried but did not express the neo gene retained a provirus of LTR-gag-pol-neo-LTR, where LTR is a long terminal repeat, whereas all G418-resistant lines deleted regions that included the primer binding site and the splicing donor site. This suggested the presence of multiple inhibitory elements.

    Original languageEnglish (US)
    Pages (from-to)4431-4433
    Number of pages3
    JournalJournal of Virology
    Volume63
    Issue number10
    StatePublished - Jan 1 1989

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    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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