TY - JOUR
T1 - Demystifying extrachromosomal DNA circles
T2 - Categories, biogenesis, and cancer therapeutics
AU - Wu, Manrong
AU - Rai, Kunal
N1 - Funding Information:
Some elements of the Figures are from BioRender.com. The authors thank Dr. Uttara Saran, Dr. Christopher Terranova, and Yingda Jiang for corrections and suggestions. The authors would like to acknowledge financial support from National Institutes of Health (R01CA245395, R01CA226269, R01CA222214, R21CA256278).
Publisher Copyright:
© 2022 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - Since the advent of sequencing technologies in the 1990s, researchers have focused on the association between aberrations in chromosomal DNA and disease. However, not all forms of the DNA are linear and chromosomal. Extrachromosomal circular DNAs (eccDNAs) are double-stranded, closed-circled DNA constructs free from the chromosome that reside in the nuclei. Although widely overlooked, the eccDNAs have recently gained attention for their potential roles in physiological response, intratumoral heterogeneity and cancer therapeutics. In this review, we summarize the history, classifications, biogenesis, and highlight recent progresses on the emerging topic of eccDNAs and comment on their potential application as biomarkers in clinical settings.
AB - Since the advent of sequencing technologies in the 1990s, researchers have focused on the association between aberrations in chromosomal DNA and disease. However, not all forms of the DNA are linear and chromosomal. Extrachromosomal circular DNAs (eccDNAs) are double-stranded, closed-circled DNA constructs free from the chromosome that reside in the nuclei. Although widely overlooked, the eccDNAs have recently gained attention for their potential roles in physiological response, intratumoral heterogeneity and cancer therapeutics. In this review, we summarize the history, classifications, biogenesis, and highlight recent progresses on the emerging topic of eccDNAs and comment on their potential application as biomarkers in clinical settings.
KW - Biogenesis
KW - Cancer therapeutics
KW - eccDNA classification
KW - eccDNAs
KW - Physiological response
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U2 - 10.1016/j.csbj.2022.10.033
DO - 10.1016/j.csbj.2022.10.033
M3 - Review article
C2 - 36382182
AN - SCOPUS:85141503402
SN - 2001-0370
VL - 20
SP - 6011
EP - 6022
JO - Computational and Structural Biotechnology Journal
JF - Computational and Structural Biotechnology Journal
ER -