DEPRESSED MONOCYTE CHEMOTAXIS DURING ACUTE INFLUENZA INFECTION

Eugenie S. Kleinerman, Ralph Snyderman, Charles A. Daniels

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The chemotactic responsiveness of monocytes from patients with serologically proven influenza infection has been quantified in vitro. Individuals with acute influenza had a significant (P<0·001) depression of monocyte chemotaxis. The depression ranged from 40% to 72% during acute infection but rose to normal by three weeks after recovery. When isolated mononuclear leucocytes from the recovered patients were incubated with the infecting strain of virus (Port Chalmers), a 49-54% inhibition of chemotaxis was obtained. These findings support the hypothesis that the altered immune responsiveness and increased predisposition to superinfections found frequently in patients with influenza can be due to the ability of the virus to depress monocyte function.

Original languageEnglish (US)
Pages (from-to)1063-1066
Number of pages4
JournalThe Lancet
Volume306
Issue number7944
DOIs
StatePublished - Nov 29 1975
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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