Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma

Samantha Tam; Moran Amit; Mark Zafereo; Diana Bell; Randal S. Weber

doi:10.1002/hed.25506

Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma

Samantha Tam, Moran Amit, Mark Zafereo, Diana Bell, Randal S. Weber

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Background: Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival. Methods: A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. DOI cut-points were computed. Multiple logistic regression and multivariate Cox proportional hazards models were used to assess predictors of occult nodal disease and overall survival (OS) and disease-specific survival (DSS). Results: Occult nodal disease was found in 55 (26%) of the 212 patients. DOI of 7.25 mm was most predictive for occult nodal disease and 8 mm for OS and DSS. DOI was an independent predictor of OS and DSS. Conclusion: The optimal DOI cut-point for detection of occult nodal metastasis was 7.25 and 8 mm for OS and DSS at 5 years. DOI is an independent predictor of OS and DSS.

Original language	English (US)
Pages (from-to)	177-184
Number of pages	8
Journal	Head and Neck
Volume	41
Issue number	1
DOIs	https://doi.org/10.1002/hed.25506
State	Published - Jan 2019

Keywords

lymph node excision
mouth neoplasms
prognosis
squamous cell carcinoma
tongue neoplasms

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.25506

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title = "Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma",

abstract = "Background: Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival. Methods: A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. DOI cut-points were computed. Multiple logistic regression and multivariate Cox proportional hazards models were used to assess predictors of occult nodal disease and overall survival (OS) and disease-specific survival (DSS). Results: Occult nodal disease was found in 55 (26%) of the 212 patients. DOI of 7.25 mm was most predictive for occult nodal disease and 8 mm for OS and DSS. DOI was an independent predictor of OS and DSS. Conclusion: The optimal DOI cut-point for detection of occult nodal metastasis was 7.25 and 8 mm for OS and DSS at 5 years. DOI is an independent predictor of OS and DSS.",

keywords = "lymph node excision, mouth neoplasms, prognosis, squamous cell carcinoma, tongue neoplasms",

author = "Samantha Tam and Moran Amit and Mark Zafereo and Diana Bell and Weber, {Randal S.}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2019",

month = jan,

doi = "10.1002/hed.25506",

language = "English (US)",

volume = "41",

pages = "177--184",

journal = "Head and Neck",

issn = "1043-3074",

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TY - JOUR

T1 - Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma

AU - Tam, Samantha

AU - Amit, Moran

AU - Zafereo, Mark

AU - Bell, Diana

AU - Weber, Randal S.

PY - 2019/1

Y1 - 2019/1

N2 - Background: Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival. Methods: A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. DOI cut-points were computed. Multiple logistic regression and multivariate Cox proportional hazards models were used to assess predictors of occult nodal disease and overall survival (OS) and disease-specific survival (DSS). Results: Occult nodal disease was found in 55 (26%) of the 212 patients. DOI of 7.25 mm was most predictive for occult nodal disease and 8 mm for OS and DSS. DOI was an independent predictor of OS and DSS. Conclusion: The optimal DOI cut-point for detection of occult nodal metastasis was 7.25 and 8 mm for OS and DSS at 5 years. DOI is an independent predictor of OS and DSS.

AB - Background: Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival. Methods: A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. DOI cut-points were computed. Multiple logistic regression and multivariate Cox proportional hazards models were used to assess predictors of occult nodal disease and overall survival (OS) and disease-specific survival (DSS). Results: Occult nodal disease was found in 55 (26%) of the 212 patients. DOI of 7.25 mm was most predictive for occult nodal disease and 8 mm for OS and DSS. DOI was an independent predictor of OS and DSS. Conclusion: The optimal DOI cut-point for detection of occult nodal metastasis was 7.25 and 8 mm for OS and DSS at 5 years. DOI is an independent predictor of OS and DSS.

KW - lymph node excision

KW - mouth neoplasms

KW - prognosis

KW - squamous cell carcinoma

KW - tongue neoplasms

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JO - Head and Neck

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ER -

Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma

Abstract

Keywords

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