Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue

Maria K. Jimenez; Sylvia Lam; Catherine Poh; Konstantin Sokolov

doi:10.1117/12.2057584

Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue

Maria K. Jimenez, Sylvia Lam, Catherine Poh, Konstantin Sokolov

Imaging Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Identifying depth-dependent alterations associated with epithelial cancerous lesions can be challenging in the oral cavity where variable epithelial thicknesses and troublesome keratin growths are prominent. Spectroscopic methods with enhanced depth resolution would immensely aid in isolating optical properties associated with malignant transformation. Combining multiple beveled fibers, oblique collection geometry, and polarization gating, oblique polarized reflectance spectroscopy (OPRS) achieves depth sensitive detection. We report promising results from a clinical trial of patients with oral lesions suspected of dysplasia or carcinoma demonstrating the potential of OPRS for the analysis of morphological and architectural changes in the context of multilayer, epithelial oral tissue..

Original language	English (US)
Title of host publication	Translational Biophotonics
Publisher	SPIE
ISBN (Print)	9780819496263
DOIs	https://doi.org/10.1117/12.2057584
State	Published - 2014
Event	Translational Biophotonics - Houston, TX, United States Duration: May 19 2014 → May 20 2014

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9155
ISSN (Print)	1605-7422

Other

Other	Translational Biophotonics
Country/Territory	United States
City	Houston, TX
Period	5/19/14 → 5/20/14

Keywords

depth-sensitive
oral cancer diagnosis
polarized light
reflectance spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2057584

Cite this

@inproceedings{1d4cfc5e1d1f47379f186ae757616cd6,

title = "Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue",

abstract = "Identifying depth-dependent alterations associated with epithelial cancerous lesions can be challenging in the oral cavity where variable epithelial thicknesses and troublesome keratin growths are prominent. Spectroscopic methods with enhanced depth resolution would immensely aid in isolating optical properties associated with malignant transformation. Combining multiple beveled fibers, oblique collection geometry, and polarization gating, oblique polarized reflectance spectroscopy (OPRS) achieves depth sensitive detection. We report promising results from a clinical trial of patients with oral lesions suspected of dysplasia or carcinoma demonstrating the potential of OPRS for the analysis of morphological and architectural changes in the context of multilayer, epithelial oral tissue..",

keywords = "depth-sensitive, oral cancer diagnosis, polarized light, reflectance spectroscopy",

author = "Jimenez, {Maria K.} and Sylvia Lam and Catherine Poh and Konstantin Sokolov",

year = "2014",

doi = "10.1117/12.2057584",

language = "English (US)",

isbn = "9780819496263",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

booktitle = "Translational Biophotonics",

}

TY - GEN

T1 - Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue

AU - Jimenez, Maria K.

AU - Lam, Sylvia

AU - Poh, Catherine

AU - Sokolov, Konstantin

PY - 2014

Y1 - 2014

N2 - Identifying depth-dependent alterations associated with epithelial cancerous lesions can be challenging in the oral cavity where variable epithelial thicknesses and troublesome keratin growths are prominent. Spectroscopic methods with enhanced depth resolution would immensely aid in isolating optical properties associated with malignant transformation. Combining multiple beveled fibers, oblique collection geometry, and polarization gating, oblique polarized reflectance spectroscopy (OPRS) achieves depth sensitive detection. We report promising results from a clinical trial of patients with oral lesions suspected of dysplasia or carcinoma demonstrating the potential of OPRS for the analysis of morphological and architectural changes in the context of multilayer, epithelial oral tissue..

AB - Identifying depth-dependent alterations associated with epithelial cancerous lesions can be challenging in the oral cavity where variable epithelial thicknesses and troublesome keratin growths are prominent. Spectroscopic methods with enhanced depth resolution would immensely aid in isolating optical properties associated with malignant transformation. Combining multiple beveled fibers, oblique collection geometry, and polarization gating, oblique polarized reflectance spectroscopy (OPRS) achieves depth sensitive detection. We report promising results from a clinical trial of patients with oral lesions suspected of dysplasia or carcinoma demonstrating the potential of OPRS for the analysis of morphological and architectural changes in the context of multilayer, epithelial oral tissue..

KW - depth-sensitive

KW - oral cancer diagnosis

KW - polarized light

KW - reflectance spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84906311339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906311339&partnerID=8YFLogxK

U2 - 10.1117/12.2057584

DO - 10.1117/12.2057584

M3 - Conference contribution

AN - SCOPUS:84906311339

SN - 9780819496263

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Translational Biophotonics

PB - SPIE

T2 - Translational Biophotonics

Y2 - 19 May 2014 through 20 May 2014

ER -

Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this