Description of a new human breast cancer cell line, IIB-BR-G, established from a primary undifferentiated tumor

Laura Bover, Marcela Barrio, Irma Slavutsky, Alicia I. Bravo, Carlos Quintans, Ana Bagnati, Baltasar Lema, Jorge Schiaffi, Roberto Yomha, Jose Mordoh

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The establishment of a new human breast cancer cell line (IIB-BR-G) was successful after a previous growth of the cells isolated from a breast primary tumor in a female nude mouse. The IIB-BR-G cell line and the primary tumor do not express estrogen or progesterone receptors. Vimentin and keratin expression were found in the cell line and in the nude mouse tumor. This cell line displays high morphological heterogeneity with atypical multinucleated megacells, and it is capable of anchorage-independent growth and tumor formation in nude mice. The cytogenetic analysis confirmed its human origin and revealed multiple marker chromosomes and extensive chromosomal alterations including rearrangements, gains, losses, isochromosomes, and double minutes (DMs).

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalBreast Cancer Research and Treatment
Volume19
Issue number1
DOIs
StatePublished - Sep 1991
Externally publishedYes

Keywords

  • breast cancer
  • cell line
  • cytogenetics
  • morphology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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