Abstract
In this work, a set of structurally diverse synthetic carbazoles was screened for their anticancer activities. According to structure-activity relationship studies, carbazoles with an N-substituted sulfonyl group exhibited better anticancer activity. Moreover, compound 8h was discovered to show the most potent anticancer effects on Capan-2 cells by inducing apoptosis and cell cycle arrest in G2/M phase. Finally, the in vivo study demonstrated that 8h prevented the tumor growth in PANC-1 and Capan-2 xenograft models without apparent toxicity.
Original language | English (US) |
---|---|
Pages (from-to) | 17183-17190 |
Number of pages | 8 |
Journal | RSC Advances |
Volume | 8 |
Issue number | 31 |
DOIs | |
State | Published - 2018 |
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering