TY - JOUR
T1 - Desmoplastic melanoma of the periorbital region
AU - Thakar, Sudip
AU - Kandl, Thomas
AU - Sagiv, Oded
AU - Tripathy, Devjyoti
AU - Tetzlaff, Michael T.
AU - Kapur, Sahil
AU - Myers, Jeffrey
AU - Hwu, Wen Jen
AU - Jaber, Bashar M.Y.
AU - Esmaeli, Bita
N1 - Publisher Copyright:
Copyright © 2017 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Desmoplastic melanoma (DM) is a rare subtype of melanoma and an even smaller proportion of periocular melanomas. Here, the authors report 2 cases of DM in the periocular region. Staged according to the American Joint Committee on Cancer (AJCC) eighth edition classification, patient 1 presented with a stage IIIC (pT4apN1cM0) DM in the left lateral canthus with upper and lower eyelid and patient 2 presented with a stage IIIB (T4aN1bM0) DM in the left brow and supraorbital region with a parotid lymph node metastasis. In both patients, the lesions were amelanotic, with inflammatory appearance, and had been noted for several years before the correct diagnosis was made. In both patients, wide excision led to large surgical defects, and perineural invasion prompted adjuvant radiation therapy postoperatively. Patient 2 was treated with an immune checkpoint inhibitor for his parotid metastasis. Ophthalmologists should be aware of DM, its neurotrophic nature, and potential to metastasize with locally advanced lesions.
AB - Desmoplastic melanoma (DM) is a rare subtype of melanoma and an even smaller proportion of periocular melanomas. Here, the authors report 2 cases of DM in the periocular region. Staged according to the American Joint Committee on Cancer (AJCC) eighth edition classification, patient 1 presented with a stage IIIC (pT4apN1cM0) DM in the left lateral canthus with upper and lower eyelid and patient 2 presented with a stage IIIB (T4aN1bM0) DM in the left brow and supraorbital region with a parotid lymph node metastasis. In both patients, the lesions were amelanotic, with inflammatory appearance, and had been noted for several years before the correct diagnosis was made. In both patients, wide excision led to large surgical defects, and perineural invasion prompted adjuvant radiation therapy postoperatively. Patient 2 was treated with an immune checkpoint inhibitor for his parotid metastasis. Ophthalmologists should be aware of DM, its neurotrophic nature, and potential to metastasize with locally advanced lesions.
UR - http://www.scopus.com/inward/record.url?scp=85050673839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050673839&partnerID=8YFLogxK
U2 - 10.1097/IOP.0000000000001015
DO - 10.1097/IOP.0000000000001015
M3 - Article
C2 - 29194286
AN - SCOPUS:85050673839
SN - 0740-9303
VL - 34
SP - e48-e52
JO - Ophthalmic plastic and reconstructive surgery
JF - Ophthalmic plastic and reconstructive surgery
IS - 2
ER -