Abstract
A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at δ=5.0 ppm before enzyme activity, and a second CEST signal appears at δ=9.0 ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of sulfatase activity.
Original language | English (US) |
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Pages (from-to) | 6491-6495 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 22 |
Issue number | 19 |
DOIs | |
State | Published - May 4 2016 |
Externally published | Yes |
Keywords
- NMR imaging
- diagnostic agents
- enzyme kinetics
- kinetics
- sulfatases
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry