Detection of variant Ph-positive chronic myelogenous leukemia involving chromosomes 1, 9, and 22 by fluorescence in situ hybridization

David C. Seong, Pu Liu, Jeanette Siciliano, Ying Zhao, Ann Cork, Elizabeth Henske, Dorothy Warburton, Min Tsung Yu, Richard E Champlin, J. M. Trujillo, Albert Deisseroth, Michael J. Siciliano

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Abstract

Probes made by inter-Alu-PCR from an interspecific somatic cell hybrid containing only the distal half of the 9q as its only human genomic content when used for fluorescence in situ hybridization (FISH) on the cells of a chronic myelogenous leukemia (CML) patient detected involvement of chromosome 9 in a complex translocation that was not observed by standard G-band cytogenetics.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume65
Issue number2
DOIs
StatePublished - Jan 1 1993

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Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Hybrid Cells
Chromosomes, Human, Pair 1
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Fluorescence In Situ Hybridization
Cytogenetics
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Detection of variant Ph-positive chronic myelogenous leukemia involving chromosomes 1, 9, and 22 by fluorescence in situ hybridization. / Seong, David C.; Liu, Pu; Siciliano, Jeanette; Zhao, Ying; Cork, Ann; Henske, Elizabeth; Warburton, Dorothy; Yu, Min Tsung; Champlin, Richard E; Trujillo, J. M.; Deisseroth, Albert; Siciliano, Michael J.

In: Cancer Genetics and Cytogenetics, Vol. 65, No. 2, 01.01.1993, p. 100-103.

Research output: Contribution to journalArticle

Seong, DC, Liu, P, Siciliano, J, Zhao, Y, Cork, A, Henske, E, Warburton, D, Yu, MT, Champlin, RE, Trujillo, JM, Deisseroth, A & Siciliano, MJ 1993, 'Detection of variant Ph-positive chronic myelogenous leukemia involving chromosomes 1, 9, and 22 by fluorescence in situ hybridization', Cancer Genetics and Cytogenetics, vol. 65, no. 2, pp. 100-103. https://doi.org/10.1016/0165-4608(93)90214-7
Seong, David C. ; Liu, Pu ; Siciliano, Jeanette ; Zhao, Ying ; Cork, Ann ; Henske, Elizabeth ; Warburton, Dorothy ; Yu, Min Tsung ; Champlin, Richard E ; Trujillo, J. M. ; Deisseroth, Albert ; Siciliano, Michael J. / Detection of variant Ph-positive chronic myelogenous leukemia involving chromosomes 1, 9, and 22 by fluorescence in situ hybridization. In: Cancer Genetics and Cytogenetics. 1993 ; Vol. 65, No. 2. pp. 100-103.
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AU - Henske, Elizabeth

AU - Warburton, Dorothy

AU - Yu, Min Tsung

AU - Champlin, Richard E

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AU - Deisseroth, Albert

AU - Siciliano, Michael J.

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