@article{9831658340be4783beef467904b8eef7,
title = "Determinants of patient-reported xerostomia among long-term oropharyngeal cancer survivors",
abstract = "Background: This study was conducted to identify clinicodemographic risk factors for xerostomia among long-term oropharyngeal cancer (OPC) survivors. Methods: This cross-sectional study included 906 disease-free, adult OPC survivors with a median survival duration at the time of survey of 6 years (range, 1-16 years); self-reported xerostomia scores were available for 877 participants. Study participants had completed curative treatment between January 2000 and December 2013 and responded to a survey administered from September 2015 to July 2016. The primary outcome variable was cancer patient–reported xerostomia measured with the MD Anderson Symptom Inventory Head and Neck Cancer Module. Clinicodemographic risk factors for moderate to severe xerostomia were identified via multivariable logistic regression. Results: Moderate to severe xerostomia was reported by 343 of the respondents (39.1%). Female sex (odds ratio [OR], 1.82; 95% CI, 1.22-2.71; P =.003; Bayesian false-discovery probability [BFDP] = 0.568), high school or lower education (OR, 1.73; 95% CI, 1.19-2.52; P =.004; BFDP = 0.636), and current cigarette smoking at the time of survey (OR, 2.56; 95% CI, 1.19-5.47; P =.016; BFDP = 0.800) were risk factors for moderate to severe xerostomia, and bilateral intensity-modulated radiotherapy (IMRT) combined with proton therapy and ipsilateral IMRT were protective. Conclusions: In this large xerostomia study, modern radiotherapy was a protective factor, and continued cigarette smoking at the time of survey, female sex, and high school or lower education were identified as other contributing risk factors associated with moderate to severe xerostomia. Importantly, these findings need to be confirmed in prospective studies. These results can inform future research and targeted patient-centered interventions to monitor and manage radiation therapy–associated xerostomia and preserve quality of life among patients with OPC.",
keywords = "dry mouth, oropharyngeal cancer, survivorship, treatment-related effect, xerostomia",
author = "Puja Aggarwal and Hutcheson, {Katherine A.} and Garden, {Adam S.} and Mott, {Frank E.} and Charles Lu and Goepfert, {Ryan P.} and Fuller, {Clifton D.} and Lai, {Stephen Y.} and Gunn, {G. Brandon} and Chambers, {Mark S.} and Sturgis, {Erich M.} and Hanna, {Ehab Y.} and Sanjay Shete",
note = "Funding Information: Katherine A. Hutcheson reports funding from the Patient‐Centered Outcomes Research Institute, THRIVE Foundation grants, and an MD Anderson institutional research grant; personal fees from MedBridge, Inc, ATOS Medical, and the American Speech Language Hearing Association; and an unpaid role with the Head and Neck Center Alliance. Clifton D. Fuller reports funding from the National Institutes of Health (P30CA016672, R01CA258827, R01CA214825, R01DE028290, R25EB025787, R01CA218148, and R01CA225190), the National Science Foundation (1933369), the National Institutes of Health/Oncospace (subaward R43CA254559), and Elekta AB (grant, contract, and in‐kind support); travel support and honoraria from Elekta AB and the American Association of Physicists in Medicine; waivers of meeting fees from the American Society for Radiation Oncology and the European Society for Therapeutic Radiation Oncology; and roles with the American Society of Clinical Oncology/, the , and the American Society for Radiation Oncology. The other authors made no disclosures. Journal of Clinical Cancer Informatics Journal of Imaging Informatics Funding Information: This study was supported by the National Cancer Institute (5P30CA016672 to Sanjay Shete), by a Cancer Prevention Fellowship supported by the Cancer Prevention and Research Institute of Texas (grant RP170259 to Puja Aggarwal; principal investigators S. Chang and Sanjay Shete), and by the Betty B. Marcus Chair in Cancer Prevention (to Sanjay Shete). The OPC Survivorship Survey data collection was supported by the Charles and Daneen Stiefel Oropharynx Fund. This study was also supported by the Alvin R. Tarlov and John E. Ware Jr. Post‐Doctoral Award in Patient‐Reported Outcomes for 2020‐2021 (to Puja Aggarwal). The funding sources had no role in the design or conduct of the study; in the collection, management, analysis, or interpretation of the data; in the preparation, review, or approval of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2021 American Cancer Society.",
year = "2021",
month = dec,
day = "1",
doi = "10.1002/cncr.33849",
language = "English (US)",
volume = "127",
pages = "4470--4480",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "23",
}