Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography

Megan C. Jacobsen; Xinhui Duan; Dianna Cody; Erik Cressman; Dawid Schellingerhout; Rick R. Layman

doi:10.1117/12.2293935

Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography

Megan C. Jacobsen, Xinhui Duan, Dianna Cody, Erik Cressman, Dawid Schellingerhout, Rick R. Layman

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

Multiple studies in the literature have proposed diagnostic thresholds based on Multi-Energy Computed Tomography (MECT) iodine maps. However, it is critical to determine the minimum detectable iodine concentration for MECT systems to assure the clinical accuracy for various measured concentrations for these image types. In this study, seven serial dilutions of iohexol were made with concentrations from 0.03 to 2.0 mg Iodine/mL in 50 mL centrifuge tubes. The dilutions and one blank vial were scanned five times each in two scatter conditions: within a 20.0 cm diameter (Head) phantom, and a 30.0 cm x 40.0 cm elliptical (Body) phantom. This was repeated on a total of six scanners from three vendors: fast-kVp switching, dual-source dual-energy CT, dual-layer detector CT, and split-filter CT. Scan parameters and dose were matched as closely as possible across systems, and iodine maps were reconstructed. Regions-of-Interest (ROIs) were placed on 5 consecutive images within each vial, for a total of 25 measurements per sample. The mean and standard deviation were calculated for each sample. The Limit of Detection (LOD) was defined as the concentration that had a 95% chance of having a signal above the 95% confidence interval of the measured blank samples. The range of LODs was 0.021 - 0.484 mg I/mL in the head phantom and 0.125 - 0.547 mg I/mL in the body phantom. The LOD for iodinated contrast using MECT systems changed with scatter and attenuation conditions. The limit of detection for all conditions was under 0.5 mg Iodine/mL.

Original language	English (US)
Title of host publication	Medical Imaging 2018
Subtitle of host publication	Physics of Medical Imaging
Editors	Taly Gilat Schmidt, Guang-Hong Chen, Joseph Y. Lo
Publisher	SPIE
ISBN (Electronic)	9781510616356
DOIs	https://doi.org/10.1117/12.2293935
State	Published - 2018
Event	Medical Imaging 2018: Physics of Medical Imaging - Houston, United States Duration: Feb 12 2018 → Feb 15 2018

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10573
ISSN (Print)	1605-7422

Other

Other	Medical Imaging 2018: Physics of Medical Imaging
Country/Territory	United States
City	Houston
Period	2/12/18 → 2/15/18

Keywords

CT
Dual-Energy CT
Multi-Energy CT
Quantification
Spectral CT

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2293935

Cite this

Jacobsen, M. C., Duan, X., Cody, D., Cressman, E., Schellingerhout, D., & Layman, R. R. (2018). Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography. In T. G. Schmidt, G.-H. Chen, & J. Y. Lo (Eds.), Medical Imaging 2018: Physics of Medical Imaging Article 105734Q (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10573). SPIE. https://doi.org/10.1117/12.2293935

Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography. / Jacobsen, Megan C.; Duan, Xinhui; Cody, Dianna et al.
Medical Imaging 2018: Physics of Medical Imaging. ed. / Taly Gilat Schmidt; Guang-Hong Chen; Joseph Y. Lo. SPIE, 2018. 105734Q (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10573).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jacobsen, MC, Duan, X, Cody, D, Cressman, E , Schellingerhout, D & Layman, RR 2018, Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography. in TG Schmidt, G-H Chen & JY Lo (eds), Medical Imaging 2018: Physics of Medical Imaging., 105734Q, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10573, SPIE, Medical Imaging 2018: Physics of Medical Imaging, Houston, United States, 2/12/18. https://doi.org/10.1117/12.2293935

Jacobsen MC, Duan X, Cody D, Cressman E , Schellingerhout D , Layman RR. Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography. In Schmidt TG, Chen GH, Lo JY, editors, Medical Imaging 2018: Physics of Medical Imaging. SPIE. 2018. 105734Q. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2293935

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title = "Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography",

abstract = "Multiple studies in the literature have proposed diagnostic thresholds based on Multi-Energy Computed Tomography (MECT) iodine maps. However, it is critical to determine the minimum detectable iodine concentration for MECT systems to assure the clinical accuracy for various measured concentrations for these image types. In this study, seven serial dilutions of iohexol were made with concentrations from 0.03 to 2.0 mg Iodine/mL in 50 mL centrifuge tubes. The dilutions and one blank vial were scanned five times each in two scatter conditions: within a 20.0 cm diameter (Head) phantom, and a 30.0 cm x 40.0 cm elliptical (Body) phantom. This was repeated on a total of six scanners from three vendors: fast-kVp switching, dual-source dual-energy CT, dual-layer detector CT, and split-filter CT. Scan parameters and dose were matched as closely as possible across systems, and iodine maps were reconstructed. Regions-of-Interest (ROIs) were placed on 5 consecutive images within each vial, for a total of 25 measurements per sample. The mean and standard deviation were calculated for each sample. The Limit of Detection (LOD) was defined as the concentration that had a 95% chance of having a signal above the 95% confidence interval of the measured blank samples. The range of LODs was 0.021 - 0.484 mg I/mL in the head phantom and 0.125 - 0.547 mg I/mL in the body phantom. The LOD for iodinated contrast using MECT systems changed with scatter and attenuation conditions. The limit of detection for all conditions was under 0.5 mg Iodine/mL.",

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N2 - Multiple studies in the literature have proposed diagnostic thresholds based on Multi-Energy Computed Tomography (MECT) iodine maps. However, it is critical to determine the minimum detectable iodine concentration for MECT systems to assure the clinical accuracy for various measured concentrations for these image types. In this study, seven serial dilutions of iohexol were made with concentrations from 0.03 to 2.0 mg Iodine/mL in 50 mL centrifuge tubes. The dilutions and one blank vial were scanned five times each in two scatter conditions: within a 20.0 cm diameter (Head) phantom, and a 30.0 cm x 40.0 cm elliptical (Body) phantom. This was repeated on a total of six scanners from three vendors: fast-kVp switching, dual-source dual-energy CT, dual-layer detector CT, and split-filter CT. Scan parameters and dose were matched as closely as possible across systems, and iodine maps were reconstructed. Regions-of-Interest (ROIs) were placed on 5 consecutive images within each vial, for a total of 25 measurements per sample. The mean and standard deviation were calculated for each sample. The Limit of Detection (LOD) was defined as the concentration that had a 95% chance of having a signal above the 95% confidence interval of the measured blank samples. The range of LODs was 0.021 - 0.484 mg I/mL in the head phantom and 0.125 - 0.547 mg I/mL in the body phantom. The LOD for iodinated contrast using MECT systems changed with scatter and attenuation conditions. The limit of detection for all conditions was under 0.5 mg Iodine/mL.

AB - Multiple studies in the literature have proposed diagnostic thresholds based on Multi-Energy Computed Tomography (MECT) iodine maps. However, it is critical to determine the minimum detectable iodine concentration for MECT systems to assure the clinical accuracy for various measured concentrations for these image types. In this study, seven serial dilutions of iohexol were made with concentrations from 0.03 to 2.0 mg Iodine/mL in 50 mL centrifuge tubes. The dilutions and one blank vial were scanned five times each in two scatter conditions: within a 20.0 cm diameter (Head) phantom, and a 30.0 cm x 40.0 cm elliptical (Body) phantom. This was repeated on a total of six scanners from three vendors: fast-kVp switching, dual-source dual-energy CT, dual-layer detector CT, and split-filter CT. Scan parameters and dose were matched as closely as possible across systems, and iodine maps were reconstructed. Regions-of-Interest (ROIs) were placed on 5 consecutive images within each vial, for a total of 25 measurements per sample. The mean and standard deviation were calculated for each sample. The Limit of Detection (LOD) was defined as the concentration that had a 95% chance of having a signal above the 95% confidence interval of the measured blank samples. The range of LODs was 0.021 - 0.484 mg I/mL in the head phantom and 0.125 - 0.547 mg I/mL in the body phantom. The LOD for iodinated contrast using MECT systems changed with scatter and attenuation conditions. The limit of detection for all conditions was under 0.5 mg Iodine/mL.

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Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography

Abstract

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Keywords

ASJC Scopus subject areas

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