Determination of the protonation constants of gadolinium(III) diethyltriaminepentaacetic acid by solvent extraction and ICP-AES

Thomas J. Manning; Warren Fiskus; Mike Mitchell; Leigh Dees

doi:10.1080/00387019909349998

Determination of the protonation constants of gadolinium(III) diethyltriaminepentaacetic acid by solvent extraction and ICP-AES

Thomas J. Manning
, Warren Fiskus
, Mike Mitchell
, Leigh Dees

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The first and second protonation constant (logβ₁₁₁, logβ₁₂₁) of the metal-ligand complex Gadolinium(III)-diethyltriamine-pentaacetic acid (DTPA) have been determined to be 2.27 and 1.52 at 25°C and I = 0.1. A technique in which the three complexes (H₂Gd-DTPA, HGd-DTPA^-1, Gd-DTPA^-2) are separated according to their relative polarity is utilized. An inductively coupled plasma-atomic emission spectrometer (ICP-AES) is used to determine the relative concentrations of each species by monitoring the gadolinium concentration.

Original language	English (US)
Pages (from-to)	463-467
Number of pages	5
Journal	Spectroscopy Letters
Volume	32
Issue number	3
DOIs	https://doi.org/10.1080/00387019909349998
State	Published - 1999
Externally published	Yes

Keywords

Contrast reagent
DTPA
Gadolinium
Magnetic resonance imaging
Protonation

ASJC Scopus subject areas

Analytical Chemistry
Atomic and Molecular Physics, and Optics
Spectroscopy

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10.1080/00387019909349998

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title = "Determination of the protonation constants of gadolinium(III) diethyltriaminepentaacetic acid by solvent extraction and ICP-AES",

abstract = "The first and second protonation constant (logβ111, logβ121) of the metal-ligand complex Gadolinium(III)-diethyltriamine-pentaacetic acid (DTPA) have been determined to be 2.27 and 1.52 at 25°C and I = 0.1. A technique in which the three complexes (H2Gd-DTPA, HGd-DTPA-1, Gd-DTPA-2) are separated according to their relative polarity is utilized. An inductively coupled plasma-atomic emission spectrometer (ICP-AES) is used to determine the relative concentrations of each species by monitoring the gadolinium concentration.",

keywords = "Contrast reagent, DTPA, Gadolinium, Magnetic resonance imaging, Protonation",

author = "Manning, \{Thomas J.\} and Warren Fiskus and Mike Mitchell and Leigh Dees",

year = "1999",

doi = "10.1080/00387019909349998",

language = "English (US)",

volume = "32",

pages = "463--467",

journal = "Spectroscopy Letters",

issn = "0038-7010",

publisher = "Taylor and Francis Ltd.",

number = "3",

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TY - JOUR

T1 - Determination of the protonation constants of gadolinium(III) diethyltriaminepentaacetic acid by solvent extraction and ICP-AES

AU - Manning, Thomas J.

AU - Fiskus, Warren

AU - Mitchell, Mike

AU - Dees, Leigh

PY - 1999

Y1 - 1999

N2 - The first and second protonation constant (logβ111, logβ121) of the metal-ligand complex Gadolinium(III)-diethyltriamine-pentaacetic acid (DTPA) have been determined to be 2.27 and 1.52 at 25°C and I = 0.1. A technique in which the three complexes (H2Gd-DTPA, HGd-DTPA-1, Gd-DTPA-2) are separated according to their relative polarity is utilized. An inductively coupled plasma-atomic emission spectrometer (ICP-AES) is used to determine the relative concentrations of each species by monitoring the gadolinium concentration.

AB - The first and second protonation constant (logβ111, logβ121) of the metal-ligand complex Gadolinium(III)-diethyltriamine-pentaacetic acid (DTPA) have been determined to be 2.27 and 1.52 at 25°C and I = 0.1. A technique in which the three complexes (H2Gd-DTPA, HGd-DTPA-1, Gd-DTPA-2) are separated according to their relative polarity is utilized. An inductively coupled plasma-atomic emission spectrometer (ICP-AES) is used to determine the relative concentrations of each species by monitoring the gadolinium concentration.

KW - Contrast reagent

KW - DTPA

KW - Gadolinium

KW - Magnetic resonance imaging

KW - Protonation

UR - https://www.scopus.com/pages/publications/26844537043

UR - https://www.scopus.com/pages/publications/26844537043#tab=citedBy

U2 - 10.1080/00387019909349998

DO - 10.1080/00387019909349998

M3 - Article

AN - SCOPUS:26844537043

SN - 0038-7010

VL - 32

SP - 463

EP - 467

JO - Spectroscopy Letters

JF - Spectroscopy Letters

IS - 3

ER -

Determination of the protonation constants of gadolinium(III) diethyltriaminepentaacetic acid by solvent extraction and ICP-AES

Abstract

Keywords

ASJC Scopus subject areas

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