@article{8a587207999149d283e891b2681f7f37,
title = "Development and validation of a contouring guideline for the taste bud bearing tongue mucosa",
abstract = "Purpose: To introduce a contouring guideline for the taste bud bearing tongue mucosa for head and neck cancer patients receiving radiotherapy. Methods and Materials: CT simulation images of oropharyngeal cancer patients were used to delineate both the whole tongue (extrinsic/intrinsic tongue muscles, floor of mouth) and the taste bud bearing tongue mucosa (method A: adaptation of the whole tongue structure; method B: axial adaptation of a mid-sagittal contour). Volumetric and dosimetric parameters of the whole tongue and the two methods of mucosal delineation, spatial overlap between methods A and B, and inter-observer variability for method B were calculated. Results: The study cohort was comprised of 70 patients with T1–4 N0–1 tonsillar (83%) and base of tongue (17%) cancers. Most of the comparative parameters between the whole tongue and mucosa (method A) significantly differed (mean, minimum, and maximum dose, V5–V70, D40–D90). The mean dose calculated for the whole tongue deviated on average 3.77 Gy compared to method A. No significant differences were found between methods A and B of the taste bud bearing tongue mucosa structure, and none of the dosimetric parameters differed more than 1.03 Gy on average. The mean Dice similarity coefficient for both mucosal structures was 0.79 ± 0.05, and 0.63 ± 0.12 for the inter-observer analysis of method B. Conclusions: We defined two methods for delineating the taste bud bearing mucosa and both are equally satisfactory procedures. Either method is preferable over delineation of the whole tongue as organ at risk for taste impairment.",
keywords = "Guideline, Head and neck neoplasms, Organs at risk, Radiotherapy, Taste, Tongue",
author = "Sonja Stieb and Mohamed, {Abdallah S.R.} and Renjie He and Zhu, {Lin L.} and McDonald, {Brigid A.} and Kareem Wahid and {van Dijk}, {Lisanne V.} and Juan Ventura and Sara Ahmed and Lance McCoy and Deshpande, {Tanaya S.} and Stephen Grant and Reddy, {Jay P.} and Jack Phan and Garden, {Adam S.} and Rosenthal, {David I.} and Frank, {Steven J.} and Gunn, {G. Brandon} and Fuller, {C. David}",
note = "Funding Information: S. Stieb is funded by the Swiss Cancer League (BIL KLS-4300-08-2017). B.A. McDonald receives research support from the National Institutes of Health / National Institute of Dental and Craniofacial Research ( 1F31DE029093-01A1 ) and a Dr. John J. Kopchick Fellowship through the MD Anderson UTHealth Graduate School of Biomedical Sciences . K. Wahid is supported by a training fellowship from The University of Texas Health Science Center at Houston Center for Clinical and Translational Sciences TL1 Program (Grant No. TL1 TR003169 ). J. Ventura is funded through a Research Supplement to Promote Diversity in Health-Related Research by the National Cancer Institute of the National Institutes of Health ( R01CA218148 ). S.J. Frank is a paid consultant/advisory board member for Varian and advisory board member for Hitachi and Breakthrough Chronic Care. He is founder and director of and has received grants and personal fees from C4 Imaging. He reports grants from Eli Lilly, Elekta, grants and honoraria from Hitachi and personal fees from Boston Scientific and the National Comprehensive Cancer Center (NCCN). G.B. Gunn is supported by a philanthropic donation made by the Family of Paul W. Beach. C.D. Fuller received funding from the National Institute for Dental and Craniofacial Research Award (1R01DE025248-01/R56DE025248) and Academic-Industrial Partnership Award (R01 DE028290), the National Science Foundation (NSF), Division of Mathematical Sciences, Joint NIH/NSF Initiative on Quantitative Approaches to Biomedical Big Data (QuBBD) Grant (NSF 1557679), the NIH Big Data to Knowledge (BD2K) Program of the National Cancer Institute (NCI) Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science Award (1R01CA214825), the NCI Early Phase Clinical Trials in Imaging and Image-Guided Interventions Program (1R01CA218148), the NIH/NCI Cancer Center Support Grant (CCSG) Pilot Research Program Award from the UT MD Anderson CCSG Radiation Oncology and Cancer Imaging Program (P30CA016672), the NIH/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Award (P50 CA097007) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Research Education Program (R25EB025787). He has received direct industry grant support, speaking honoraria and travel funding from Elekta AB. None of the funding sources had an influence on study design, the collection, analysis and interpretation of data, the writing of the report, and the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2020",
year = "2021",
month = apr,
doi = "10.1016/j.radonc.2020.11.012",
language = "English (US)",
volume = "157",
pages = "63--69",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
}