Development of a β-HPV vaccine: Updates on an emerging frontier of skin cancer prevention

Rohit Gupta, Peter L. Rady, Hung Q. Doan, Stephen K. Tyring

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Human papillomaviruses (HPVs) are small, non-enveloped, doublestranded DNA viruses. Over 200 subtypes of HPV have been identified, organized into five major genera. β-HPVs are a group of approximately 50 HPV subtypes that preferentially infect cutaneous sites. While α-HPVs are primarily responsible for genital lesions and mucosal cancers, growing evidence has established an association between β-HPVs and the development of cutaneous squamous cell carcinomas. Given this association, the development of a vaccine against β-HPVs has become an important topic of research; however, currently licensed vaccines only provide coverage for genital HPVs, leaving β-HPV infections and their associated skin cancers unaddressed. In this review, we summarize the current advances in β-HPV vaccine development, including progress made in preclinical testing and limited clinical data. We also discuss novel findings in the viral pathomechanisms involved in β-HPV cutaneous tumorigenesis that may play a large role in future vaccine development. We hope that synthesizing the available data and advances surrounding β- HPV vaccine development will not only lead to increased dedication to vaccine development, but also heightened awareness of a future vaccine among clinicians and the public.

Original languageEnglish (US)
Article number104348
JournalJournal of Clinical Virology
StatePublished - May 2020


  • Cutaneous squamous cell carcinoma
  • Humanpapilloma virus
  • Skin cancer prevention
  • Vaccine
  • β-HPV

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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