Development of research into autophagic lysosome reformation

Yang Chen, Li Yu

Research output: Contribution to journalShort surveypeer-review

39 Scopus citations

Abstract

Autophagy is a lysosome-dependent degradation process that is essential for maintaining cellular homeostasis. In recent years, more studies have focused on the late stages of autophagy. Our group discovered and studied the terminal step of autophagy, namely autophagic lysosome reformation (ALR). ALR is the process that regenerates functional lysosomes from autolysosomes, thus maintaining lysosome homeostasis. ALR involves clathrin-mediated membrane budding from autolysosomes, elongation of membrane tubules along microtubules with the pulling force provided by the motor protein KIF5B, proto-lysosome scission by dynamin 2, and finally maturation of proto-lysosomes to functional lysosomes. In this review, we will summarize progress in unveiling the molecular mechanisms underlying ALR and its potential pathophysiological roles.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalMolecules and cells
Volume41
Issue number1
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • Autophagic lysosome reformation (ALR)
  • Autophagy
  • In vitro reconstitution
  • Membrane deformation
  • Phospholipid

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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