Diagnosis of lymphoma using fine-needle aspiration biopsy and core-needle biopsy: A single-institution experience

Fatima Zahra Jelloul, Maria Navarro, Pooja Navale, Tamla Hagan, Rubina S. Cocker, Kasturi Das, Lisa Rosen, Xinmin Zhang, Silvat Sheikh-Fayyaz

Research output: Contribution to journalArticle


Objective: The objective is to study the efficacy of fine-needle aspiration biopsy (FNAB) and core-needle biopsy (CNB) in the diagnosis of lymphoma in a single institution. Study Design: We retrospectively reviewed 635 FNAB/CNB cases performed in our institution to rule out lymphoma during a 4-year period and collected the relevant clinical and pathological information for statistical analysis. Results and Conclusions: This cohort comprised 275 males and 360 females, with a median age of 57 years. Among the 593 cases with adequate diagnostic materials for lymphoma work-up, 226 were positive for lymphoma, 286 were negative for lymphoma, and 81 were nondiagnostic. Each case had an FNAB, and 191 cases also underwent a CNB. The subclassification rate according to the WHO (2008) was 67% overall, 81% for the FNAB with CNB group, and 40% for the FNAB group. In the FNAB with CNB group, the subclassification rates for cases with and without a history of lymphoma were not significantly different. A definitive diagnosis of lymphoma relied on ancillary studies, but was not affected by location, or the needle gauge of CNB. Follow-up data revealed a high diagnostic accuracy of FNAB with CNB. In conclusion, the use of FNAB and CNB with ancillary studies is effective in providing a definitive diagnosis of lymphoma in our experience at the Northwell Health System.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalActa Cytologica
Issue number3
StatePublished - Jan 1 2019



  • Core-needle biopsy
  • Fine-needle aspiration biopsy
  • Lymphoma
  • Subclassification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Jelloul, F. Z., Navarro, M., Navale, P., Hagan, T., Cocker, R. S., Das, K., Rosen, L., Zhang, X., & Sheikh-Fayyaz, S. (2019). Diagnosis of lymphoma using fine-needle aspiration biopsy and core-needle biopsy: A single-institution experience. Acta Cytologica, 63(3), 198-205. https://doi.org/10.1159/000497252