Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together

Research output: Contribution to journalArticle

Abstract

The spectrum of T-cell lymphoid proliferations of the skin varies from indolent to highly aggressive diseases and therefore an accurate pathological diagnosis is paramount. Integration of clinical, histopathological, immunohistochemical, and molecular findings is of crucial importance in the evaluation of these processes. In this article, we discuss selected situations where difficulty may arise for the pathologist evaluating this type of skin biopsies, such as: the diagnosis of early (patch stage) mycosis fungoides, the distinction of mycosis fungoides with large cell transformation from primary cutaneous anaplastic large cell lymphoma, the recognition of new histopathological patterns of lymphomatoid papulosis and the entities they mimic, the evaluation of primary cutaneous anaplastic large cell lymphoma with expression of markers suggestive of systemic origin (such as ALK), the awareness of the wide range of clinical and pathological presentations of hydroa vacciniforme-like EBV-positive T-cell lymphoproliferative disorders, the evaluation of cases of primary cutaneous γδ T-cell lymphoma showing predominantly epidermotropic pattern of growth, and the correct interpretation of findings seen in indolent proliferations such as primary cutaneous acral CD8-positive T-cell lymphoma and primary cutaneous small/medium size CD4 + T-cell lymphoproliferative disorder.

Original languageEnglish (US)
Pages (from-to)83-95
Number of pages13
JournalModern Pathology
Volume33
DOIs
StatePublished - Jan 1 2020

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Primary Cutaneous Anaplastic Large Cell Lymphoma
Cutaneous T-Cell Lymphoma
Mycosis Fungoides
Lymphoproliferative Disorders
Cell Proliferation
T-Lymphocytes
Skin
Hydroa Vacciniforme
Lymphomatoid Papulosis
Human Herpesvirus 4
Extremities
Biopsy
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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Diagnosis of T-cell lymphoid proliferations of the skin : putting all the pieces together. / Torres-Cabala, Carlos A.

In: Modern Pathology, Vol. 33, 01.01.2020, p. 83-95.

Research output: Contribution to journalArticle

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