TY - JOUR
T1 - Diagnostic opportunities based on skin biomarkers
AU - Paliwal, Sumit
AU - Hwang, Byeong Hee
AU - Tsai, Kenneth Y.
AU - Mitragotri, Samir
N1 - Funding Information:
K.Y.T. acknowledges the funding support of DX Biosciences, Cancer Research Fund, MD Anderson Cancer IRG Program, the American Skin Association, and institutional funds. SM acknowledges support from DX Biosciences.
PY - 2013
Y1 - 2013
N2 - Systemic as well as localized skin diseases modify the molecular composition of human skin. Changes in skin chemistry have been observed in diseases such as cancer, psoriasis, eczema, diabetes, and atherosclerosis. Skin chemistry, represented by an enormous wealth of disease biomarkers including lipids, structural proteins, inflammatory mediators, nucleic acids and small molecules, therefore, can serve as a "window to body's health". Various methods including tape-stripping, iontophoresis, microneedles and ultrasound, among others, are being developed to access skin biomarkers and understand skin's detailed molecular composition. This information provides opportunities to diagnose various diseases and their response to therapeutic treatments. This review provides an overview of such diagnostic and theranostic opportunities.
AB - Systemic as well as localized skin diseases modify the molecular composition of human skin. Changes in skin chemistry have been observed in diseases such as cancer, psoriasis, eczema, diabetes, and atherosclerosis. Skin chemistry, represented by an enormous wealth of disease biomarkers including lipids, structural proteins, inflammatory mediators, nucleic acids and small molecules, therefore, can serve as a "window to body's health". Various methods including tape-stripping, iontophoresis, microneedles and ultrasound, among others, are being developed to access skin biomarkers and understand skin's detailed molecular composition. This information provides opportunities to diagnose various diseases and their response to therapeutic treatments. This review provides an overview of such diagnostic and theranostic opportunities.
KW - Biochemistry
KW - Biomarkers
KW - Diagnostics
KW - Non-invasive
KW - Skin
UR - http://www.scopus.com/inward/record.url?scp=84885957762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885957762&partnerID=8YFLogxK
U2 - 10.1016/j.ejps.2012.10.009
DO - 10.1016/j.ejps.2012.10.009
M3 - Review article
C2 - 23159445
AN - SCOPUS:84885957762
SN - 0928-0987
VL - 50
SP - 546
EP - 556
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
IS - 5
ER -