Diagnostic opportunities based on skin biomarkers

Sumit Paliwal, Byeong Hee Hwang, Kenneth Y Tsai, Samir Mitragotri

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Systemic as well as localized skin diseases modify the molecular composition of human skin. Changes in skin chemistry have been observed in diseases such as cancer, psoriasis, eczema, diabetes, and atherosclerosis. Skin chemistry, represented by an enormous wealth of disease biomarkers including lipids, structural proteins, inflammatory mediators, nucleic acids and small molecules, therefore, can serve as a "window to body's health". Various methods including tape-stripping, iontophoresis, microneedles and ultrasound, among others, are being developed to access skin biomarkers and understand skin's detailed molecular composition. This information provides opportunities to diagnose various diseases and their response to therapeutic treatments. This review provides an overview of such diagnostic and theranostic opportunities.

Original languageEnglish (US)
Pages (from-to)546-556
Number of pages11
JournalEuropean Journal of Pharmaceutical Sciences
Volume50
Issue number5
DOIs
StatePublished - Jan 1 2013

Fingerprint

Biomarkers
Skin
Iontophoresis
Eczema
Psoriasis
Skin Diseases
Nucleic Acids
Atherosclerosis
Lipids
Health
Therapeutics
Neoplasms
Proteins

Keywords

  • Biochemistry
  • Biomarkers
  • Diagnostics
  • Non-invasive
  • Skin

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Diagnostic opportunities based on skin biomarkers. / Paliwal, Sumit; Hwang, Byeong Hee; Tsai, Kenneth Y; Mitragotri, Samir.

In: European Journal of Pharmaceutical Sciences, Vol. 50, No. 5, 01.01.2013, p. 546-556.

Research output: Contribution to journalReview article

Paliwal, Sumit ; Hwang, Byeong Hee ; Tsai, Kenneth Y ; Mitragotri, Samir. / Diagnostic opportunities based on skin biomarkers. In: European Journal of Pharmaceutical Sciences. 2013 ; Vol. 50, No. 5. pp. 546-556.
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