Diagnostic opportunities based on skin biomarkers

Sumit Paliwal, Byeong Hee Hwang, Kenneth Y. Tsai, Samir Mitragotri

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Systemic as well as localized skin diseases modify the molecular composition of human skin. Changes in skin chemistry have been observed in diseases such as cancer, psoriasis, eczema, diabetes, and atherosclerosis. Skin chemistry, represented by an enormous wealth of disease biomarkers including lipids, structural proteins, inflammatory mediators, nucleic acids and small molecules, therefore, can serve as a "window to body's health". Various methods including tape-stripping, iontophoresis, microneedles and ultrasound, among others, are being developed to access skin biomarkers and understand skin's detailed molecular composition. This information provides opportunities to diagnose various diseases and their response to therapeutic treatments. This review provides an overview of such diagnostic and theranostic opportunities.

Original languageEnglish (US)
Pages (from-to)546-556
Number of pages11
JournalEuropean Journal of Pharmaceutical Sciences
Volume50
Issue number5
DOIs
StatePublished - 2013

Keywords

  • Biochemistry
  • Biomarkers
  • Diagnostics
  • Non-invasive
  • Skin

ASJC Scopus subject areas

  • Pharmaceutical Science

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