Dietary B vitamin and methionine intakes and lung cancer risk among female never smokers in China

Yumie Takata, Qiuyin Cai, Alicia Beeghly-Fadiel, Honglan Li, Martha J. Shrubsole, Bu Tian Ji, Gong Yang, Wong Ho Chow, Yu Tang Gao, Wei Zheng, Xiao Ou Shu

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Purpose: B vitamins and methionine have been postulated to have potential effects on carcinogenesis; however, findings from previous epidemiologic studies on B vitamins, methionine, and lung cancer risk are inconsistent. We investigated associations of dietary intakes of B vitamins (i.e., riboflavin, niacin, vitamin B6, folate, and vitamin B12) and methionine with lung cancer risk among female never smokers. Methods: The Shanghai Women's Health Study, a population-based, prospective cohort study, included 74,941 women. During a median follow-up of 11.2 years, 428 incident lung cancer cases accrued among 71,267 women with no history of smoking or cancer at baseline. Baseline dietary intakes were derived from a validated, interviewer-administered food frequency questionnaire. Cancer incidence and vital status were ascertained through annual linkage to the Shanghai Cancer Registry and Shanghai Vital Statistics Registry databases and through biennial in-person follow-ups with participants. Adjusted hazard ratios (HR) and 95 % confidence intervals (CI) were calculated using Cox regression. Results: Dietary riboflavin intake was inversely associated with lung cancer risk (HR = 0.62; 95 % CI = 0.43-0.89; p trend = 0.03 for the highest quartile compared with the lowest). A higher than median intake of methionine was associated with lower risk of lung cancer (HR = 0.78; 95 % CI = 0.60-0.99); however, there was no dose-response relation. Intakes of other B vitamins were not associated with lung cancer risk. Conclusions: Our study suggests that dietary riboflavin intake may be inversely associated with lung cancer risk among female never smokers, which warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1965-1975
Number of pages11
JournalCancer Causes and Control
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2012

Keywords

  • B vitamins
  • Lung cancer
  • Methionine
  • Never smokers
  • Women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Takata, Y., Cai, Q., Beeghly-Fadiel, A., Li, H., Shrubsole, M. J., Ji, B. T., Yang, G., Chow, W. H., Gao, Y. T., Zheng, W., & Shu, X. O. (2012). Dietary B vitamin and methionine intakes and lung cancer risk among female never smokers in China. Cancer Causes and Control, 23(12), 1965-1975. https://doi.org/10.1007/s10552-012-0074-z