@inbook{9695d439e2b84b088cb286cece44098c,
title = "Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models",
abstract = "Pancreatic cancer remains an unmet medical need. Late diagnosis and the lack of efficient treatment significantly impact the prognosis of patients suffering from pancreatic cancer. Improving patient outcomes requires a deeper comprehension of the tumor ecosystem. To achieve this, a thorough exploration of the tumor microenvironment using pre-clinical models that accurately replicate human disease is imperative, particularly in understanding the dynamics of immune cell subsets. Surprisingly, the impact of model variations on the composition of the tumor microenvironment has been largely neglected. In this study, we introduce an orthotopic model of pancreatic ductal adenocarcinoma and a spontaneous model of insulinoma. Our findings reveal striking differences in the innate lymphoid cell infiltrate, highlighting the importance of considering model-specific influences when investigating the tumor microenvironment.",
keywords = "Flow cytometry, ILC2, Innate lymphoid cells, Insulinoma, Mouse model, Pancreatic cancer, PDAC, Tumor microenvironment",
author = "Sara Lamorte and Elford, \{Alisha R.\} and Chung, \{Douglas C.\} and Kiichi Murakami and McGaha, \{Tracy L.\} and Nicolas Jacquelot",
note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",
year = "2024",
month = jan,
doi = "10.1016/bs.mcb.2024.04.001",
language = "English (US)",
isbn = "9780443222405",
series = "Methods in Cell Biology",
publisher = "Academic Press Inc.",
pages = "153--169",
editor = "\{Bravo-San Pedro\}, \{Jos{\'e} Manuel\} and Fernando Aranda and Aitziber Buqu{\'e} and Lorenzo Galluzzi",
booktitle = "Animal Models of Disease - Part B",
}